| survivin基因在膀胱移行细胞癌中的表达及其意义 |
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| 引用本文： | 张家俊,李庆文,王萍,承泽农. survivin基因在膀胱移行细胞癌中的表达及其意义[J]. 蚌埠医学院学报, 2007, 32(2): 139-141 |
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| 作者姓名： | 张家俊 李庆文 王萍 承泽农 |
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| 作者单位： | 1. 蚌埠医学院附属医院 泌尿外科, 安徽 蚌埠 233004;2. 蚌埠医学院 病理学教研室, 安徽 蚌埠 233030 |
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| 摘 要： | 目的: 探讨survivin基因在膀胱移行细胞癌(transitional cell carcinoma of bladder,TCCB)发生、发展和复发中的作用。方法: 对53例膀胱移行细胞癌和10例正常膀胱黏膜应用原位杂交方法检测survivin mRNA的表达。结果: survivin mRNA在正常的膀胱黏膜中无表达,在TCCB中的阳性表达率为71.7%,两者差异有统计学意义(P<0.005);survivin mRNA在TCCB中的阳性表达率随TCCB的病理分级、临床分期升高而增高,在G1、G2和G3级TCCB中的阳性表达率分别是50.0%、68.2%和94.1%,差异有统计学意义(P<0.005);在表浅性和浸润性TCCB中的阳性表达率分别为50.0%、92.6%,阳性表达率两者差异有统计学意义(P<0.01);在初发和复发TCCB中的阳性表达率分别为66.7%、85.7%,两者阳性表达率差异有统计学意义(P<0.05)。结论: survivin mRNA高水平表达在TCCB的发生、发展和复发中发挥了重要作用。
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| 关 键 词： | 膀胱肿瘤 癌 移行细胞 suvivin基因 原位杂交 细胞凋亡 |
| 文章编号： | 1000-2200（2007）02-0139-03 |
| 收稿时间： | 2006-01-20 |
| 修稿时间： | 2006-01-20 |
Expression and clinicopathologic significance of surviving mRNA in transitional cell carcinoma of bladder |
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| ZHANG Jia-jun,LI Qing-wen,WANG Ping,CHENG Ze-nong. Expression and clinicopathologic significance of surviving mRNA in transitional cell carcinoma of bladder[J]. Journal of Bengbu Medical College, 2007, 32(2): 139-141 |
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| Authors: | ZHANG Jia-jun LI Qing-wen WANG Ping CHENG Ze-nong |
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| Affiliation: | 1. Department of Urology, Affiliated Hospital of Bengbu Medical College, Bengbu 233004;2. Department of Pathology, Bengbu Medical College, Bengbu 233030, China |
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| Abstract: | Objective:To investigate the expression of survivin mRNA and to evaluate its effects on the tumorigenesis,progression and recurrence in transitional cell carcinoma of bladder(TCCB).Methods:In 53 cases of TCCBs and 10 cases of normal bladder mucosas,the expression level of survivin mRNA was detected by in situ hybridization(ISH).Results:The expression positive rate of survivin mRNA in TCCB(71.7%) was significantly higher than that in 10 normal bladder tissues(P<0.005).The expression level of surviving mRNA was elevated as the grade and stage increased in TCCB.The positive rates in grade G1,G2,G3 were 50.0%,68.2% and 94.1%(P<0.005),50.0% and 92.6% in stage of Ta-T1,T2-T4,respectively.All the data in above groups were statistically significant(P<0.01);and in primary and recurrent cases were 66.7% and 85.7% and the data was statistically significant(P<0.05).Conclusions:The higher expression of survivin mRNA may play an important role in the tumorignesis,development and recurrence of TCCB. |
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| Keywords: | bladder neoplasm carcinoma, transitional cell survivin gene in situ hybridization apoptosis |
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