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| 乙肝Ⅲ号内外合用治疗慢性乙型肝炎后肝纤维化63例 | |
| 引用本文： | 邢宇锋,张希,邵丽,王丽娜,童光东. 乙肝Ⅲ号内外合用治疗慢性乙型肝炎后肝纤维化63例[J]. 世界华人消化杂志, 2007, 15(5): 522-527 |
| 作者姓名： | 邢宇锋 张希 邵丽 王丽娜 童光东 |
| 作者单位： | 广州中医药大学附属深圳医院肝病科,广东省深圳市,518033 |
| 摘 要： | 目的:观察乙肝Ⅲ号内外合用治疗慢性乙型肝炎后肝纤维化的远期疗效.方法:随机选择乙肝肝纤维化患者240例,分为乙肝Ⅲ号外用膏组(n=58),内服组(n=62),内外合用组(n=63),对照组(n=57).治疗后3 mo,观察各组临床症状、肝功能、肝纤维化指数、PGA参数、血液动力学等.结果:4组皆能改善临床症状,但以内外合用组为著;4组改善肝功能、肝纤三项、PGA参数,治疗后3 mo以内外合用组疗效显著(t=6.1201,P=0.000;t=20.8201,P=0.000;t=20.5154,P=0.000);血液动力学检测显示,各治疗组治疗后门、脾静脉血管直径、血流量皆有下降(t=3.6153,P=0.0004;t=6.8052,P=0.000),内外合用组血流量下降明显(t=6.3969,P=0.000).随访12 mo后仍是内外合用组疗效为优.但各组在抗病毒指标上,无统计学意义.结论:乙肝Ⅲ号内外合用治疗乙肝后肝纤维化有一定远期疗效,且较单一方法疗效明显,疗程以3 mo为优. |
| 关 键 词： | 慢性乙型肝炎 肝纤维化 中药 内外合用 乙肝后肝纤维化 内外合用 治疗组 慢性乙型 肝炎后肝纤维化 chronic hepatitis B liver fibrosis treatment application external internal combined 疗效明显 统计学意义 指标 病毒 随访 血流量 血管直径 脾静脉 |
| 收稿时间： | 2006-11-20 |
| 修稿时间： | 2006-11-20 |
Long-term efficacy of combined internal and external application of Ganyan Sanhao in treatment of liver fibrosis resulted from chronic hepatitis B |
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| Yu-Feng Xing,Xi Zhang,Li Shao,Li-Na Wang,Guang-Dong Tong. Long-term efficacy of combined internal and external application of Ganyan Sanhao in treatment of liver fibrosis resulted from chronic hepatitis B[J]. World Chinese Journal of Digestology, 2007, 15(5): 522-527 | |
| Authors: | Yu-Feng Xing Xi Zhang Li Shao Li-Na Wang Guang-Dong Tong |
| Abstract: | AIM: To observe the prospective efficacy of integrated internal and external application of Yigan Sanhao (YGSH) in the treatment of liver fibrosis resulted from chronic hepatitis B (CHB).METHODS: A total of 240 inpatients with CHB-induced liver fibrosis were randomly divided into group A (n = 58), B (n = 62), C (n = 63) and D (n = 57). External, internal and integrated external and internal treatments of YGSH were performed on the patients of group A, B, and C, respectively. The patients of group D served as controls. The clinical symptoms, liver function, fibrosis and PGA parameters, and hemodynamic changes were observed 3 months after treat-ment.RESULTS: The clinical symptoms were im-proved, especially in group C. The liver func-tion, fibrosis and PGA parameters were alsoameliorated 3 months after treatment in all the groups, especially in group C (t = 6.1201, P = 0.000; t = 20.8201, P = 0.000; t = 20.5154, P = 0.000). Hemodynamic examination showed that the diameters of splenic and portal vein as well as the blood flow were decreased in all the groups (t = 3.6153, P = 0.0004; t = 6.8052, P = 0.000), es-pecially significant in group C (t = 6.3969, P = 0.000). A 12-month following-up demonstrated that combination of external and internal appli-cation had the most favorable effect. However, the anti-viral efficacy was not markedly different between the four groups.CONCLUSION: Integrated internal and exter-nal application of YGSH has a favorable long-term efficacy, and it is superior to the single use. Three-month course is considered the most optimal. |
| Keywords: | Chronic hepatitis B Liver fibrosis Tra-ditional Chinese medicine Combined treatment |
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