The effects ofAstragalus membranaceus andTripterygium hypoglaucum on NK activity in systemic lupus erythematosus |
| |
| Authors: | Xiao-zhong Zhao and Fu-ren Liu |
| |
| Affiliation: | 1. Department of Dermatology, General Air Force Hospital, 100036, Beijing
2. Department of Dermatology, 2nd Affiliated Hospital of Xi’an Medical University, 710006, Xi’an
|
| |
| Abstract: | The natural killer cell activity of peripheral blood mononuclear cells from 28 patients with systemic lupus erythematosus was measured using enzyme-release assay. The patients exhibited obviously decreased natural killer cell activity compared with the healthy subjects in the control group. The natural killer cell dysfunction was related to steroidal therapy, but not to three auto-antibodies. The release of a soluble natural killer cytotoxic factor by the peripheral blood mononuclear cells was tested by cytotoxicity assay induced in K562 cells. This release was significantly lower in the test group than in the control group. Pre-incubation of peripheral blood mononuclear cells withAstragalus membranaceus andTripterygium hypoglaucum considerably enhanced natural killer cytotoxicity by stimulating the release of soluble cytotoxic factors. |
| |
| Keywords: | Astragalus membranaceus Tripterygium hypoglaucum natural killer cell activity natural killer cytotoxic factor systemic lupus erythematosus |
| 本文献已被 SpringerLink 等数据库收录！ |
| 点击此处可从《中国结合医学杂志》浏览原始摘要信息 |
|
点击此处可从《中国结合医学杂志》下载免费的PDF全文 |
