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Multiple genetically modified GTKO/hCD46/HLA‐E/hβ2−mg porcine hearts are protected from complement activation and natural killer cell infiltration during ex vivo perfusion with human blood
Authors:Jan‐Michael Abicht  Riccardo Sfriso  Bruno Reichart  Matthias Längin  Katja Gahle  Gisella L. Puga Yung  Jörg D. Seebach  Robert Rieben  David Ayares  Eckhard Wolf  Nikolai Klymiuk  Andrea Baehr  Alexander Kind  Tanja Mayr  Andreas Bauer
Affiliation:1. Department of Anaesthesiology, Ludwig Maximilian University, Munich, Germany;2. Department of Clinical Research, University of Bern, Bern, Switzerland;3. Transregio Collaborative Research Center 127, Walter Brendel Centre of Experimental Medicine, Ludwig Maximilian University, Munich, Germany;4. Division of Immunology and Allergology, University Hospital and Faculty of Medicine, University of Geneva, Geneva, Switzerland;5. Revivicor, Blacksburg, VA, USA;6. Department of Molecular Animal Breeding and Biotechnology, Ludwig Maximilian University, Munich, Germany;7. Chair of Livestock Biotechnology, School of Life Sciences Weihenstephan, Technical University of Munich, Munich, Germany
Abstract:
Keywords:cardiac xenotransplantation  hCD46  heart     HLAE     NK cell
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