| Effect of Acupuncture on Uncoupling Protein 1 Gene Expression for Brown Adipose Tissue of Obese Rats |
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| 引用本文： | Liu Zhi-cheng,Sun Feng-min,Zhao Dong-hong,Zhang Zhong-cheng,Sun Zhi,Wu Hai-tao,Xu Bing-guo,Zhu Miao-hu,Li Chao-jun. Effect of Acupuncture on Uncoupling Protein 1 Gene Expression for Brown Adipose Tissue of Obese Rats[J]. 中国结合医学杂志, 2003, 9(3): 204-209. DOI: 10.1007/BF02838034 |
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| 作者姓名： | Liu Zhi-cheng Sun Feng-min Zhao Dong-hong Zhang Zhong-cheng Sun Zhi Wu Hai-tao Xu Bing-guo Zhu Miao-hu Li Chao-jun |
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| 作者单位： | Nanjing University of TCM，Nanjing 210029，Nanjing Population Administration College，Nanjing Normal University，Nanjing University of TCM，Nanjing 210029，Nanjing University of TCM，Nanjing 210029，Nanjing University of TCM，Nanjing 210029，Nanjing University of TCM，Nanjing 210029，Nanjing University of TCM，Nanjing 210029，Nanjing Normal University |
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| 基金项目： | The item is supported by the National Nature Science Foundation(No.39970923) |
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| 摘 要： | Objective:To explore the effects of acupuncture on the expression of uncoupling protein 1(UCP_1)gene of brown adipose tissue (BAT)in obese rats.Methods:The expression of UCP_1 gene ofBAT was determined with RT-PCR technique.The changes of body weight,Lee’s index,body fat,andthe expression of UCP_1 gene of BAT in obese rats were observed before and after acupuncture.Results:The body weight,Lee’s indeX,body fat in obese rats were all markedly higher than those in normal rats,but the expression of UCP_1 gene of BAT in obese rats was all lower than that in normal rats.There werenegative correlation between the Obesity index and the expression of UCP_1 gent in BAT.After acupunc-ture the marked effect of weight loss was achieved while the expression of UCP_1 gene of BAT Obviously in-creased in obese rats.Conclusion:The abnormal reduction for expression of UCP_1 gene of BAT might bean important cause for the obesity.To promote the expression of UCP_1 in obese organism might be an im-portant cellular and mole
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| 收稿时间： | 2003-06-05 |
Effect of acupuncture on uncoupling protein 1 gene expression for brown adipose tissue of obese rats |
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| Liu Zhi-cheng,Sun Feng-min,Zhao Dong-hong,Zhang Zhong-cheng,Sun Zhi,Wu Hai-tao,Xu Bing-guo,Zhu Miao-hua and Li Chao-jun. Effect of acupuncture on uncoupling protein 1 gene expression for brown adipose tissue of obese rats[J]. Chinese journal of integrative medicine, 2003, 9(3): 204-209. DOI: 10.1007/BF02838034 |
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| Authors: | Liu Zhi-cheng Sun Feng-min Zhao Dong-hong Zhang Zhong-cheng Sun Zhi Wu Hai-tao Xu Bing-guo Zhu Miao-hua Li Chao-jun |
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| Abstract: | Objective: To explore the effects of acupuncture on the expression of uncoupling protein 1 (UCP1) gene of brown adipose tissue (BAT) in obese rats.Methods: The expression of UCP1 gene of BAT was determined with RT-PCR technique. The changes of body weight, Lee's index, body fat, and the expression of UCP1 gene of BAT in obese rats were observed before and after acupuncture. Results: The body weight, Lee's index, body fat in obese rats were all markedly higher than those in normal rats, but the expression of UCP1 gene of BAT in obese rats was all lower than that in normal rats. There were negative correlation between the obesity index and the expression of UCP1 gene in BAT. After acupuncture the marked effect of weight loss was achieved while the expression of UCP1 gene of BAT obviously increased in obese rats. Conclusion: The abnormal reduction for expression of UCP1 gene of BAT might be an important cause for the obesity. To promote the expression of UCP1 in obese organism might be an important cellular and molecular mechanism in anti-obesity effect by acupuncture. |
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| Keywords: | acupuncture obesity uncoupling protein gene |
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