Keratin 6 is not essential for mammary gland development |
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| Authors: | Sandra L Grimm Wen Bu Mary Ann Longley Dennis R Roop Yi Li Jeffrey M Rosen |
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| Affiliation: | (1) Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, 77030 Houston, TX, USA;(2) Breast Center, Baylor College of Medicine, One Baylor Plaza, 77030 Houston, TX, USA |
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| Abstract: | Introduction Keratin 6 (K6) has previously been identified as a marker of early mammary gland development and has also been proposed to be a marker of mammary gland progenitor cells. However, the function of K6 in the mammary gland was not known, so we examined the expression pattern of the protein during both embryonic and postnatal mammary development, as well as the mammary gland phenotype of mice that were null for both K6a and K6b isoforms. |
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