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Antioxidant power of angiotensin-converting enzyme inhibitors in vitro |
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| Authors: | Iris F. F. Benzie,& Brian Tomlinson |
| Affiliation: | Department of Nursing &Health Sciences, The Hong Kong Polytechnic University,;Department of Clinical Pharmacology, The Chinese University of Hong Kong, Hong Kong |
| Abstract: | Aims There is controversy regarding the potential antioxidant effect of captopril, therefore this study was performed to compare the in vitro antioxidant power of captopril with other angiotensin-converting enzyme (ACE) inhibitors. Methods Antioxidant power of captopril, enalapril, fosinopril, perindopril, quinapril and ramipril in aqueous solution was measured using the ferric reducing (antioxidant) power (FRAP) assay; captopril was also measured in ethanolic solution. Results Only captopril showed significant antioxidant power, demonstrating a stoichiometric factor of 1.0 in this assay. Concentration-related antioxidant power was seen in both aqueous and ethanolic solutions. Conclusions Captopril shows antioxidant activity in vitro . This property could be relevant in vivo if captopril is concentrated in membranes, lipoproteins or at other important sites. |
| Keywords: | captopril hypertension ACE inhibitor antioxidant CHD ROS oxidative stress FRAP assay |