| 术前外周血淋巴细胞与单核细胞比值评估直肠癌预后的价值 |
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| 引用本文： | 雷娟,张鸿文,王瑜,丘建燊,黄增亮,张芨,杨超,吴伟航. 术前外周血淋巴细胞与单核细胞比值评估直肠癌预后的价值[J]. 现代肿瘤医学, 2021, 0(1): 77-80. DOI: 10.3969/j.issn.1672-4992.2021.01.017 |
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| 作者姓名： | 雷娟 张鸿文 王瑜 丘建燊 黄增亮 张芨 杨超 吴伟航 |
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| 作者单位： | 1.福建医科大学福总临床医学院（联勤保障部队第900医院）医学影像介入病房；2.胃肠外科，福建 福州 350025 |
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| 基金项目： | 福建省科学技术厅对外合作项目(编号:2017I0015)。 |
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| 摘 要： | 目的:探讨直肠癌患者术前外周血淋巴细胞与单核细胞比值（LMR）与预后的关系。方法:回顾性分析2007年1月至2012年1月我院收治的85例行直肠癌根治术患者的临床资料，根据受时间依赖受试者生存曲线（ROC）将患者分为高LMR组和低LMR组。分析直肠癌患者LMR水平与临床病理特征的相关性；采用Kaplan-Meier法进行单因素生存分析，Cox风险回归模型用于多因素分析。结果:根据ROC曲线，LMR最佳临界值为4.21，其中高LMR组58例，低LMR组27例，高LMR组与低LMR组之间的脉管癌栓发生率、癌胚抗原（CEA）水平和TNM分期有统计学差异（P<0.05）；年龄、性别、病理类型、术后是否接受放化疗等方面无统计学差异（P>0.05）。单因素分析显示临床分期、术前CEA水平、脉管癌栓、LMR水平是影响直肠癌患者5年总生存率和无疾病进展生存率的危险因素（P<0.05）；高LMR组与低LMR组的5年总生存率分别为72.4%和40.7%；无疾病进展生存率分别为58.6%和25.9%；Cox多因素分析结果显示临床分期和LMR是影响直肠癌术后患者的独立预后因素。结论:LMR与直肠癌患者的术后分期相关，且LMR是直肠癌术后患者预后的独立影响因素之一，与远期生存呈正比关系，具有良好的预测价值。
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| 关 键 词： | 直肠癌 淋巴细胞/单核细胞 预后 |
The value of lymphocyte and monocyte ratio to predict the prognosis of patients with rectum cancer |
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| LEI Juan,ZHANG Hongwen,WANG Yu,QIU Jianshen,HUANG Zengliang,ZHANG Ji,YANG Chao,WU Weihang. The value of lymphocyte and monocyte ratio to predict the prognosis of patients with rectum cancer[J]. Journal of Modern Oncology, 2021, 0(1): 77-80. DOI: 10.3969/j.issn.1672-4992.2021.01.017 |
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| Authors: | LEI Juan ZHANG Hongwen WANG Yu QIU Jianshen HUANG Zengliang ZHANG Ji YANG Chao WU Weihang |
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| Affiliation: | 1.Interventional Ward Of Medical Imaging Center；2.Gastrointestinal Surgery，Clinical Institute of Fuzhou General Hospital，Fujian Medical University(900 Hospital of the Joint Logistics Team) Fujian Fuzhou 350025，China. |
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| Abstract: | Objective:To evaluate the value of lymphocyte and monocyte ratio(LMR)in predicting the prognosis of patients with rectum cancer.Methods:The 85 patients who met the criterion were enrolled to this study from January 2007 to January 2012,who were divided into high-LMR group and low-LMR group based on the standard of receiver operating characteristic curve(ROC).The relationships of LMR and clinical pathological of patients with rectum cancer was analyzed.Kaplan-Meier method was used for univariate survival and Cox hazard-ratio model was used to analyze the prognostic factors of rectum cancer.Results:The cut-off data of LMR was 4.21.The cases of high-LMR group was 58,27 in low-LMR group.The level of carcinoembryonic antigen(CEA),the rate of cancer embolus and TNM stage were significantly different between two groups(P<0.05).However,the age,gender,type of pathological and postoperative chemotherapy and radiotherapy in two groups showed no significant differences(P>0.05).Univariate survival analysis showed that level of CEA,the rate of cancer embolus,TNM stage and the value of LMR were risk factors for 5-year overall survival(OS)and progress free disease(PFS)(P<0.05).The 5-year OS and PFS were 72.4%,58.6%in high-LMR group,40.7%and 25.9%in other group(P<0.05).Cox multivariate survival analysis showed that TNM stage and LMR were independent factors for prognostic evaluation of rectum cancer patients.Conclusion:LMR level is significantly associated with TNM stage.High LMR is an independent prognostic risk factor and plays an important role in prognostic evaluation of rectum cancer patients. |
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| Keywords: | rectum cancer lymphocyte and monocyte ratio prognosis |
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