| 节律基因hBmal1在人结肠癌中的表达及临床意义 |
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| 引用本文： | 鲁力,熊治国,谢敏,熊莉娜. 节律基因hBmal1在人结肠癌中的表达及临床意义[J]. 中华结直肠疾病电子杂志, 2016, 5(4): 315-318. DOI: 10.3877/cma.j.issn.2095-3224.2016.04.007 |
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| 作者姓名： | 鲁力 熊治国 谢敏 熊莉娜 |
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| 作者单位： | 1. 430000 武汉，湖北省肿瘤医院胃肠外科2. 华中科技大学同济医学院附属梨园医院消化内科 |
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| 基金项目： | 湖北省自然科学基金资助项目(No.2013CFB117); 华中科技大学青年教师基金资助项目(No.2013QN128) |
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| 摘 要： | 目的检测hBmal1在人结肠癌中的表达，探讨其临床意义。 方法应用免疫组织化学方法检测湖北省肿瘤医院30例人结肠癌患者中hBmal1的表达，以图像分析软件进行相关测定，并分析其表达与临床及病理常用指标的关系。 结果人结肠癌组织和癌旁正常对照组织中hBmal1表达阳性率为76.67%（23/30） vs 26.67%（8/30）（χ2=15.016，P<0.01）；hBmal1在人结肠癌Dukes分期B、C期中强阳性表达率为46.15%（6/13） vs 88.24%（15/17）（χ2=6.212，P=0.013）。 结论hBmal1在人结肠癌组织中有高表达，可能与癌症的发生发展侵袭转移有关。
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| 关 键 词： | 结肠肿瘤 基因表达 节律基因 hBmal1基因 |
| 收稿时间： | 2016-05-21 |
Significance and expression of hBmal1 in human colon carcinoma |
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| Li Lu,Zhiguo Xiong,Min Xie,Lina Xiong. Significance and expression of hBmal1 in human colon carcinoma[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2016, 5(4): 315-318. DOI: 10.3877/cma.j.issn.2095-3224.2016.04.007 |
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| Authors: | Li Lu Zhiguo Xiong Min Xie Lina Xiong |
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| Affiliation: | 1. Department of Gastrointestinal Surgery, Cancer Hospital of Hubei Province, Wuhan 430000, China2. Department of Digestive Disease, Liyuan Hospital, Huazhong University of Science & Technology, Wuhan 430077, China |
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| Abstract: | ObjectiveThe aim of study is to investigate the expression of hBmal1 gene in human colon carcinoma tissue and their relation to invasion and metabasis of colon carcinoma. MethodsImmunochemical staining was performed to detect the expression of hBmal1 protein in 30 cases of colon carcinoma tissues and 30 cases of normal tissues from Cancer Hospital of Hubei Province. ResultsThe positive expression rate of hBmal1 in colon carcinoma tissues and in adjacent noncancerous tissues were 76.67% (23/30) vs 26.67% (8/30) (χ2=15.016, P<0.01). The strong positive expression rate of hBmal1 in B and C Dukes stage of were 46.15% (6/13) vs 88.24% (15/17) (χ2=6.212, P=0.013). ConclusionsIncreased expression of hBmal1 gene contributes to occurrence and development of colon carcinoma. |
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| Keywords: | Colon neoplasms Gene expression Rhythm gene hBmal1 gene |
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