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| 结直肠癌的免疫检查点阻断治疗 | |
| 引用本文： | 魏少忠,胡胜. 结直肠癌的免疫检查点阻断治疗[J]. 中华结直肠疾病电子杂志, 2016, 5(6): 468-474. DOI: 10.3877/cma.j.issn.2095-3224.2016.06.003 |
| 作者姓名： | 魏少忠 胡胜 |
| 作者单位： | 1. 430071 武汉，湖北省肿瘤医院胃肠外科2. 湖北省肿瘤医院肿瘤内科 |
| 摘 要： | 结直肠癌是常见的恶性肿瘤之一，总体预后相对较差。对转移性结直肠癌患者而言，探索更有效的治疗方法显得尤为重要。免疫治疗，特别是免疫检查点抑制剂，是近几年研究的热点，在黑色素瘤、肺癌等疾病中取得了较好的疗效。本文将重点阐述抗肿瘤免疫在结直肠癌中的作用，以及各种免疫检查点抑制剂在结直肠癌中应用的最新进展。 |
| 关 键 词： | 结直肠癌 治疗 免疫检查点 免疫治疗 |
| 收稿时间： | 2016-06-16 |
Immune checkpoints blocking treatment of colorectal cancer |
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| Shaozhong Wei,Sheng Hu. Immune checkpoints blocking treatment of colorectal cancer[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2016, 5(6): 468-474. DOI: 10.3877/cma.j.issn.2095-3224.2016.06.003 | |
| Authors: | Shaozhong Wei Sheng Hu |
| Affiliation: | 1. Department of Gastrointestinal Surgery, Hubei Cancer Hospital, Hubei Cancer Hospital, Wuhan 430071, China2. Department of Medical Oncology, Hubei Cancer Hospital, Wuhan 430071, China |
| Abstract: | Colorectal cancer is one of the most common malignacies, and the overall prognosis is not satisfying. For patients with metastatic colorectal cancer, there is an urgent need to explore new efficient treatment methods. Immunotherapy, especially immune checkpoint inhibitors, are the current research focuses, which show excellent outcomes in melanoma and lung cancer. This review will outline the antitumor immunity and the new progress of a variety of immune checkpoint inhibitors in colorectal cancer. |
| Keywords: | Colorectal neoplasms Therapy Immune checkpoint Immunotherapy |
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