Characterization of a humanized monoclonal antibody recognizing clumping factor A expressed by Staphylococcus aureus |
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| Authors: | Domanski Paul J Patel Pratiksha R Bayer Arnold S Zhang Li Hall Andrea E Syribeys Peter J Gorovits Elena L Bryant Dawn Vernachio John H Hutchins Jeff T Patti Joseph M |
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| Affiliation: | Inhibitex, Inc., 9005 Westside Parkway, Suite 400, Alpharetta, GA 30004, USA. |
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| Abstract: | We report the humanization and characterization of monoclonal antibody (MAb) T1-2 or tefibazumab, a monoclonal antibody that recognizes clumping factor A expressed on the surface of Staphylococcus aureus. We demonstrate that the binding kinetics of MAb T1-2 is indistinguishable compared to that of its murine parent. Furthermore, MAb T1-2 is shown to enhance the opsonophagocytic uptake of ClfA-coated latex beads, protect against an intravenous challenge in a prophylactic model of rabbit infective endocarditis, and enhance the efficacy of vancomycin therapy in a therapeutic model of established infective endocarditis. |
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