Telomeres, stem cells, senescence, and cancer |
| |
| Authors: | Sharpless Norman E DePinho Ronald A |
| |
| Affiliation: | Department of Medicine and Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599-8212, USA. nes@med.unc.edu |
| |
| Abstract: | Mammalian aging occurs in part because of a decline in the restorative capacity of tissue stem cells. These self-renewing cells are rendered malignant by a small number of oncogenic mutations, and overlapping tumor suppressor mechanisms (e.g., p16(INK4a)-Rb, ARF-p53, and the telomere) have evolved to ward against this possibility. These beneficial antitumor pathways, however, appear also to limit the stem cell life span, thereby contributing to aging. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
