Induction of T helper type 1 responses by a polysaccharide deacetylase from Cryptococcus neoformans |
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| Authors: | Biondo Carmelo Beninati Concetta Bombaci Mauro Messina Luciano Mancuso Giuseppe Midiri Angelina Galbo Roberta Teti Giuseppe |
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| Affiliation: | Dipartimento di Patologia e Microbiologia Sperimentale, Facoltà di Medicina e Chirurgia, Università di Messina, I-98125 Messina, Italy. |
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| Abstract: | A 25-kDa cryptococcal deacetylase (d25) was found here to induce cell proliferation, as well as secretion of interleukin 2 and gamma interferon, but not interleukin 4, in spleen cells from d25-immunized or Cryptococcus neoformans-infected mice. The gamma interferon, but not the interleukin 2, response was required for the protective activities of d25 immunization in a murine cryptococcosis model. |
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