| 三联化疗在口腔鳞癌综合治疗中的应用及其疗效评价 |
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| 引用本文： | 刘曙光,廖楚航,王大章,赵建江,艾伟健,郑俊发. 三联化疗在口腔鳞癌综合治疗中的应用及其疗效评价[J]. 华西口腔医学杂志, 2003, 21(2): 109-111 |
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| 作者姓名： | 刘曙光 廖楚航 王大章 赵建江 艾伟健 郑俊发 |
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| 作者单位： | 610041,四川大学华西口腔医院口腔颌面外科;广东省口腔医院 |
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| 基金项目： | 广东省卫生厅科研基金资助项目 (编号A2 0 0 0 1 0 94) |
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| 摘 要： | 目的 评价术前三联化疗(PYM+5-Fu+DDP)配合手术治疗口腔鳞癌的临床疗效及与多药耐药性的关系。方法 采用术前三联化疗合并手术综合方案治疗口腔鳞癌患者102例,全部患者均经活检确诊。对所有患者的化疗效果进行评价,并对综合治疗的效果进行随访观察。结果 102例患者化疗有效率为82·4%。有完整随访资料者92例,存活69例,3年生存率为67·6%。结论 本三联化疗方案在口腔鳞癌综合治疗中具有用药剂量小、疗效确切等优点,可作为口腔鳞癌患者术前化疗方案之一。
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| 关 键 词： | 化疗 口腔鳞癌 多药耐药性 |
| 收稿时间： | 2003-04-25 |
| 修稿时间： | 2002-01-21 |
The Clinical Application and Evaluation of Combined Chemotherapy in Comprehensive Treatment for Oral Squamous Cell Carcinoma |
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| LIU Shuguang,LIAO Chuhang,WANG Dazhang,et al.. The Clinical Application and Evaluation of Combined Chemotherapy in Comprehensive Treatment for Oral Squamous Cell Carcinoma[J]. West China journal of stomatology, 2003, 21(2): 109-111 |
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| Authors: | LIU Shuguang LIAO Chuhang WANG Dazhang et al. |
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| Affiliation: | West China College of Stomatology,Sichuan University,Chengdu 610041,China |
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| Abstract: | OBJECTIVE: To study and evaluate the clinical effects of combined preoperative chemotherapy and their relations with multi drug resistance (MDR). METHODS: 102 cases with oral squamous cell carcinoma(OSCC) were included in the study (63 males and 39 females, aged 22 to 67 years). Among the subjects there were 57 cases with cancer of tongue and 45 cases with cancer of buccal mucosa. 27 cases in the group were classified as stage II, 55 as stage III and 20 cases as stage IV according to TNM standard. All cases accepted PYM + 5-Fu + DDP combined chemotherapy pre-operatively. The total given dose was PYM 48 mg, 5-Fu 7.5 g and DDP 300 mg. After the chemotherapy, radical surgery were performed within 2 weeks. The diagnosis of all cases were proved as OSCC by biopsy. RESULTS: Total effective rate of the combined chemotherapy was 82.4%. All of the cases were followed up and their 3 years' survival rate was 67.6%. CONCLUSION: The combined chemotherapy of PYM + 5-Fu + DDP is effective in using as one of comprehensive treatment for OSCC. |
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| Keywords: | chemotherapy oral squamous cell carcinoma multi drug resistance |
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