| 慢性阻塞性肺疾病患者血浆肾上腺髓质素水平的变化 |
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| 引用本文： | 苏宪灵,齐菲,解立新. 慢性阻塞性肺疾病患者血浆肾上腺髓质素水平的变化[J]. 蚌埠医学院学报, 2015, 39(7): 857-859,862. DOI: 10.13898/j.cnki.issn.1000-2200.2015.07.006 |
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| 作者姓名： | 苏宪灵 齐菲 解立新 |
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| 作者单位： | 1.中国人民解放军总医院 呼吸科, 北京 100853 |
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| 基金项目： | 首都医学发展科研基金项目(2007-3050) |
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| 摘 要： | 目的:通过检测慢性阻塞性肺疾病(COPD)患者血浆肾上腺髓质素(ADM)的水平,研究ADM与COPD病情变化的相关性。方法:选择COPD急性加重期患者(加重组)、稳定期患者(稳定组)及健康体检者(对照组)各23例,检测并比较其血浆ADM水平、肺功能、血气分析、血常规。结果:加重组与稳定组血浆ADM水平均明显高于对照组(PPPP结论:随着COPD患者病情恶化,ADM代偿性增加,扩张气道,抑制炎症反应,可延缓疾病进展。
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| 关 键 词： | 肺疾病 阻塞性 肾上腺髓质素 炎症反应 |
| 收稿时间： | 2015-05-19 |
The change of plasma adrenomedullin level in patients with chronic obstructive pulmonary disease |
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| Affiliation: | 1.Department of Respiration, The General Hospital of Chinese People's Liberation Army, Beijing 100853, China |
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| Abstract: | Objective:To observe the level of the plasma adrenomedullin ( ADM ) in patients with chronic obstructive pulmonary disease( COPD) ,and investigate the correlation of ADM with COPD. Methods:The patients with COPD were divided into the acute exacerbated COPD group and stable COPD group,and the healthy people were set as the control group(23 cases each group). The plasma ADM levels,pulmonary function,blood gas analysis and blood routine test among three groups were compared. Results:The levels of plasma ADM in acute exacerbated COPD group and stable COPD group were significantly higher than that in control group (P<0. 01),and which in acute exacerbated COPD group was significantly higher than that in stable COPD group(P<0. 01). The level of plasma ADM was significantly negative correlation with the FEV1. 0%,FEV1. 0/FVC% and arterial oxygen partial pressure(P<0.01),but which was correlation with pH value(P < 0. 05). Conclusions:With the deterioration of COPD patients,the ADM compensatory increasing can expand the airway,inhibit the inflammation reaction and delay disease progression. |
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| Keywords: | pulmonary disease,chronic obstruction adrenomedullin inflammatory reaction |
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