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The release of prostaglandins and rabbit aorta contracting substance (RCS) from rabbit spleen and its antagonism by anti-inflammatory drugs |
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| Authors: | R. Gryglewski and J. R. Vane |
| Abstract: | 1. Slices of rabbit spleen generate rabbit aorta contracting substance (RCS) and a prostaglandin of the E series when they are vibrated or stirred. 2. The release of both substances is increased by arachidonic acid and inhibited by aspirin-like drugs. 3. When the spleen effluent containing RCS and prostaglandin E is incubated for a further 3 min, the prostaglandin concentration increases and the RCS concentration declines. 4. RCS may therefore be an unstable intermediate in the biosynthesis of prostaglandins. |
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