| 肝脂酶基因-250G/A多态性与脑梗死 |
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| 引用本文： | 张蕾,倪培华,傅毅,应雅韵,陆国强. 肝脂酶基因-250G/A多态性与脑梗死[J]. 诊断学理论与实践, 2006, 5(3): 239-242. DOI: 10.16150/j.1671-2870.a1081 |
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| 作者姓名： | 张蕾 倪培华 傅毅 应雅韵 陆国强 |
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| 作者单位： | 上海交通大学医学院附属瑞金医院检验系,上海交通大学医学院附属瑞金医院检验系,上海交通大学医学院附属瑞金医院神经内科,上海交通大学医学院附属瑞金医院检验系,上海交通大学医学院附属瑞金医院神经内科 上海200025 上海邮电医院检验科,上海200040,上海200025,上海200025,上海200025,上海200025 |
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| 摘 要： | 目的:探讨上海汉族人群肝脂酶基因启动子250G/A(HL-250G/A)多态性与脑梗死的关系。方法:采用聚合酶链反应-限制性片段长度多态性(PCR-RELP)技术检测133例脑梗死患者和92名正常老年人HL-250G/A多态性基因型,并研究其对血脂水平的影响。结果:脑梗死组的基因型和等位基因频率分布与正常老年组相比,均有显著差异;在男性无突变型中,脑梗死组的高密度脂蛋白胆固醇水平比正常老年组低;在女性中,脑梗死组突变型的三酰甘油水平高于同组的无突变型和正常老年组的突变型,统计学上差异均存在显著性(P
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| 关 键 词： | 肝脂酶 基因多态性 脑梗死 |
| 文章编号： | 1671-2870(2006)03-0239-04 |
| 收稿时间： | 2006-04-05 |
| 修稿时间： | 2006-04-05 |
Hepatic lipase gene -250G/A polymorphism and cerebral infarction |
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| ZHANG Lei,NI Pei-hua,FU Yi,YING Ya-yun,LU Guo-qiang. Hepatic lipase gene -250G/A polymorphism and cerebral infarction[J]. Journal of Diagnostics Concepts & Practice, 2006, 5(3): 239-242. DOI: 10.16150/j.1671-2870.a1081 |
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| Authors: | ZHANG Lei NI Pei-hua FU Yi YING Ya-yun LU Guo-qiang |
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| Affiliation: | 1a Department of Medical Laboratory; 1b. Department of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine ,Shanghai 200025,China; 2. Department of Laboratory Science, Shanghai Post and Telecommunication Hospital, 200040, China |
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| Abstract: | Objective To explore the interaction between hepatic lipase gene -250G/A polymorphism and cerebral infarction in Shanghai Han population. Methods The genotype of the hepatic lipase gene -250G/A was detected using polymerase chain reaction-restricted fragments length polymorphism technique in 133 patients with cerebral infarction and 92 healthy elders. The effect of gene polymorphism on serum lipid concentration was also studied. Results The significant difference was found in the frequencies of the genotypes and the alleles between the patients with cerebral infarction and the healthy elders. In the males without A allele, the serum high-density lipoprotein cholesterol levels in the patients with cerebral infarction were lower than those in the healthy elders; however, in the females, the serum triglyceride levels in the cerebral infarction patients with A allele were higher than those in the cerebral infarction patiets without A allele and in the healthy elders with A allele(P<0.05). Logistic regression analysis showed that systolic pressure, serum glucose and A allele were independent risk factors for cerebral infarction. Conclusions Hepatic lipase gene -250G/A polymorphism is directly related to cerebral infarction. In addition, -250G/A gene mutation in the female patients with cerebral infarction may obviously raise triglyceride levels. |
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| Keywords: | Hepatic lipase Polymorphism Cerebral infarction |
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