| 自体造血干细胞移植治疗恶性血液病疗效观察 |
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| 引用本文： | 陈芾珩,苏永忠,李回军,卢素春,庄春兰,刘元生. 自体造血干细胞移植治疗恶性血液病疗效观察[J]. 白血病．淋巴瘤, 2009, 19(10): 360-362. DOI: 10.3760/cma.j.issn.1009-9921.2010.06.014 |
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| 作者姓名： | 陈芾珩 苏永忠 李回军 卢素春 庄春兰 刘元生 |
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| 作者单位： | 汕头大学医学院第一附属医院血液科,515041; |
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| 摘 要： | Objective To observe the efficacy of autologous hematopoietic stem cell transplantation (auto-AHSCT) in treatment of malignant hemopathy. Methods A retrospective study was accomplished on the auto-AHSCT in the treatment of 28 patients with malignant hemopathy from Oct 1994 to May 2009. The median age of the patients was 30 (16-45) years. Among the 28 patients,19 cases were acute myelocytic leukemia (AML),4 cases were acute lymphoblastic leukemia (ALL) and 5 cases were malignant lymphoma (ML). Mobilization of peripheral blood stem cell was recieved by giving granulocyte colony-stimulating factor (G-CSF) 5-10 μg/kg. The patients were pretreated with melphalan (140-160 mg/m2),cyclophosphamide (120 mg/kg) and arabinosylcytosin (2 g/m2). Results Transplant-related side effects was less and the hematologic recovery of most patients(26 cases) was quite rapid. The days to stable neutrophil count of 0.5×109/L and platelet count of 20×109/L were 12(8-38) d and 14(9-128) d,respectively. The median followup duration was 36(7-68) months. 19 cases (68 %) achieved disease-free survival(DFS) and 9 cases (32 %)died in three years. Of the 9 death patients,7 cases (25 %) died of recurrence and 2 cases (7 %) died of posttransplant complications. Conclusion AHSCT is a safe and effective therapy method for malignant hemopathy.
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| 关 键 词： | 血液肿瘤 造血干细胞移植 移植,自体 |
Clinical study of autologous hematopoietic stem cell transplantation in the treatment of patients with malignant hemopathy |
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| Abstract: | |
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| Keywords: | Hematologic neoplasmsHematopoietic stem cell transplantationTransplantation autologous |
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