| 金属硫蛋白在大肠癌中的研究进展 |
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| 引用本文： | 赵轩,李国东,刘明. 金属硫蛋白在大肠癌中的研究进展[J]. 实用肿瘤学杂志, 2021, 35(6): 538-541. DOI: 10.11904/j.issn.1002-3070.2021.06.010 |
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| 作者姓名： | 赵轩 李国东 刘明 |
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| 作者单位： | 1.哈尔滨医科大学附属第四医院(哈尔滨市 150001); 2.哈尔滨医科大学附属第二医院 |
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| 基金项目： | 黑龙江省自然科学基金-联合引导项目(编号:LH2020H066) |
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| 摘 要： | 金属硫蛋白(Metallothionein,MTs)是一种小蛋白,富含半胱氨酸。MTs在人体内主要分为四个亚型(MT1、MT2、MT3、MT4)。MTs的主要功能是清除自由基和参与重金属的解毒和稳态,同时具有抗氧化的特性。相关研究发现MTs可参与DNA的损伤修复,并且参与肿瘤的发生发展,与肿瘤细胞的耐药性相关。本文将对MTs在大肠癌中的研究进展做一综述。
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| 关 键 词： | 大肠癌 金属硫蛋白 进展 |
| 收稿时间： | 2020-12-08 |
Research progress of metallothionein in colorectal cancer |
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| ZHAO Xuan,LI Guodong,LIU Ming. Research progress of metallothionein in colorectal cancer[J]. Journal of Practical Oncology, 2021, 35(6): 538-541. DOI: 10.11904/j.issn.1002-3070.2021.06.010 |
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| Authors: | ZHAO Xuan LI Guodong LIU Ming |
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| Affiliation: | 1. The Fourth Affiliated Hospital of Harbin Medical University,Harbin 150001,China; 2. The Second Affiliated Hospital of Harbin medical University |
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| Abstract: | Metallothionein(MTs)is a small protein,rich in cysteine.MTs is mainly divided into four subtypes in the human body(MT1,MT2,MT3 and MT4).The main function of MTs is to scavenge free radicals and participate in the detoxification and homeostasis of heavy metals,resulting from antioxidant properties.Recent studies have found that MTs can participate in the repair of DNA damage,and participate in the occurrence and development of tumors,and are related to the drug resistance of tumor cells.This article will review the research progress of MTs in colorectal cancer. |
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| Keywords: | Colorectal cancer Metallothionein Progress |
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