| 星点设计-效应面法优化黄玉膏成型工艺研究 |
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| 引用本文： | 张璐, 李兆玉, 蔡文腾, 陶华明. 星点设计-效应面法优化黄玉膏成型工艺研究[J]. 中国现代应用药学, 2022, 39(4): 467-474. DOI: 10.13748/j.cnki.issn1007-7693.2022.04.006 |
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| 作者姓名： | 张璐 李兆玉 蔡文腾 陶华明 |
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| 作者单位： | 1.南方医科大学中医药学院, 广东省中药制剂重点实验室, 广东省中药制剂技术工程实验室, 广州 510515 |
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| 基金项目： | 广东省中医药局科研项目(20212142， 20212143)；大学生创新创业训练计划项目(S202012121085， 201912121044) |
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| 摘 要： | 目的 运用星点设计-效应面法优化黄玉膏剂的配方基质及工艺参数。方法 采用单因素试验、正交试验,以总黄酮、黄芩苷、大黄素、盐酸小檗碱作为指标成分,优化处方提取工艺及基质组成;采用星点设计-效应面法,以软膏的感官评价和膏剂稳定常数的综合评分为考察指标,优化黄玉膏基质中甘油、单硬脂酸甘油酯和辛酸/癸酸甘油三酯(caprylic/capric triglyceride,GTCC)的最佳配比。结果 优选的最佳基质配比为丙二醇13.3%,甘油20.55%,单硬脂酸甘油酯7.75%,GTCC 23.78%。结论 通过单因素、正交试验、星点设计-效应面法3种优化工艺,获得的新型黄玉膏外观均匀细腻,黏度适中,稳定性良好。
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| 关 键 词： | 黄玉膏 基质优化 星点设计-效应面法 |
| 收稿时间： | 2021-03-25 |
Optimization of Molding Process of Huangyu Ointment by Central Composite Design-response Surface Methodology |
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| ZHANG Lu, LI Zhaoyu, CAI Wenteng, TAO Huaming. Optimization of Molding Process of Huangyu Ointment by Central Composite Design-response Surface Methodology[J]. Chinese Journal of Modern Applied Pharmacy, 2022, 39(4): 467-474. DOI: 10.13748/j.cnki.issn1007-7693.2022.04.006 |
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| Authors: | ZHANG Lu LI Zhaoyu CAI Wenteng TAO Huaming |
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| Affiliation: | 1.School of Traditional Chinese Medicine, Southern Medical University, Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, Guangdong Provincial Engineering Laboratory of Chinese Medicine Preparation Technology, Guangzhou 510515, China |
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| Abstract: | OBJECTIVE To optimize the matrix formula and technological parameter of Huangyu Ointment by using the central composite design-response surface methodology. METHODS Single factor experiment and orthogonal experiment were used to optimize the extraction process and matrix composition with total flavonoids, baicalin, emodin and berberine hydrochloride as index components. With the sensory score and stability constant of ointment as evaluation indices, chose the best matching of glycerinum, glycerin monostearate and caprylic/capric triglyceride(GTCC) by central composite design-response surface methodology. RESULTS The optimum formula consisted of 13.3% propylene glycol, 20.55% glycerinum, 7.75% glycerin monostearate and 23.78% GTCC. CONCLUSION According to the single factor, orthogonal test and central composite design-response surface methodology, the new formula of Huangyu Ointment have acquired with uniform and delicate appearance, and it have appropriate viscosity and good stability. |
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| Keywords: | Huangyu Ointment formula optimization the central composite design-response surface method |
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