| 中国老年人HDAC9和PPP3CA基因多态性与衰弱的关联 |
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| 引用本文： | 杨佩, 张宇杰, 钟文芳, 王晓萌, 吕跃斌, 毛琛. 中国老年人HDAC9和PPP3CA基因多态性与衰弱的关联[J]. 中华疾病控制杂志, 2023, 27(1): 77-81. doi: 10.16462/j.cnki.zhjbkz.2023.01.014 |
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| 作者姓名： | 杨佩 张宇杰 钟文芳 王晓萌 吕跃斌 毛琛 |
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| 作者单位： | 1.510515 广州，南方医科大学公共卫生学院流行病学系;;2.100021 北京，中国疾病预防控制中心环境与健康相关产品安全所 |
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| 基金项目： | 国家自然科学基金82173588国家自然科学基金81973109国家自然科学基金82001476 |
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| 摘 要： | 目的 探讨组蛋白去乙酰化酶9(histone deacetylase 9, HDAC9) rs2074633及钙调神经磷酸酶催化亚基A(calcineurin catalytic subunit A, PPP3CA) rs17030795的多态性与中国老年人衰弱发生的关联。方法 本研究纳入衰弱组665例，对照组3 388例。基于基因型频率及五种遗传模型(共显性、加性、显性、隐性和超显性)，评估rs2074633及rs17030795多态性与衰弱之间的关联。结果 在共显性模型中，与携带rs2074633 TT基因型相比，携带TC型(OR=1.99，95% CI: 1.36~2.90)、CC型(OR=2.15，95% CI: 1.48~3.13)的个体发生衰弱的风险增加；在加性(OR=1.28，95% CI: 1.11~1.47)、显性(OR=2.07，95% CI: 1.44~2.98)及隐形模型(OR=1.21，95% CI: 1.01~1.45)中rs2074633多态性均增加衰弱的发生风险；在共显性模型中，与携带rs17030795 AA基因型相比，携带AG(OR=1.72，95% CI: 1.19~2.51)、GG(OR=1.98，95% CI: 1.37~2.87)型的个体发生衰弱的风险增加；在加性(OR=1.28，95% CI: 1.11~1.48)、显性(OR=1.85，95% CI: 1.29~2.66)及隐性(OR=1.25，95% CI: 1.04~1.50)中rs17030795多态性均增加衰弱的发生风险。 结论 HDAC9 rs2074633及PPP3CA rs17030795多态性与中国老年人衰弱发生风险有关。
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| 关 键 词： | 衰弱 基因多态性 HDAC9基因 PPP3CA基因 |
| 收稿时间： | 2022-03-24 |
| 修稿时间： | 2022-06-19 |
Associations of single nucleotide polymorphisms of HDAC9 and PPP3CA genes with frailty in the Chinese elderly people |
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| YANG Pei, ZHANG Yu-jie, ZHONG Wen-fang, WANG Xiao-meng, LYU Yue-bin, MAO Chen. Associations of single nucleotide polymorphisms of HDAC9 and PPP3CA genes with frailty in the Chinese elderly people[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(1): 77-81. doi: 10.16462/j.cnki.zhjbkz.2023.01.014 |
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| Authors: | YANG Pei ZHANG Yu-jie ZHONG Wen-fang WANG Xiao-meng LYU Yue-bin MAO Chen |
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| Affiliation: | 1. Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China;;2. National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China |
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| Abstract: | Objective To explore the associations between the single nucleotide polymorphism (SNP) of histone deacetylase 9 (HDAC9) and calcineurin catalytic subunit A (PPP3CA) and frailty in the Chinese elderly people. Methods Our study included 665 participants in the frailty group and 3 388 participants in the control group. Associations between rs2074633 and rs17030795 gene polymorphisms and frailty were evaluated based on genotype frequencies, and five genetic models (co-dominance, additive, dominance, recessive and over-dominance models). Results In co-dominance model, individuals carrying HDAC9 rs2074633 TC genotype (OR=1.99, 95% CI: 1.36-2.90) and CC genotype (OR=2.15, 95% CI: 1.48-3.13) were more likely to develop frailty, compared with those carrying TT genotype3. The rs2074633 polymorphisms increased the risk of frailty in both additive model (OR=1.28, 95% CI: 1.11-1.47), dominant model (OR=2.07, 95% CI: 1.44-2.98) and recessive model (OR=1.21, 95% CI: 1.01-1.45). In co-dominance model, individuals carrying PPP3CA rs17030795 AG (OR=1.72, 95% CI: 1.19-2.51) genotype and GG (OR=1.98, 95% CI: 1.37-2.87) genotype were more likely to develop frailty, compared with those carrying AA genotype. The rs17030795 polymorphisms increased the risk of frailty in both additive model (OR=1.28, 95% CI: 1.11-1.48), dominant model (OR=1.85, 95% CI: 1.29-2.66) and recessive model (OR=1.25, 95% CI: 1.04-1.50). Conclusions The rs2074633and rs17030795 polymorphisms are associated with the increased risk of frailty. |
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| Keywords: | Frailty Gene polymorphism Histone deacetylase 9 Calcineurin catalytic subunit A |
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