| 胰腺癌发病的危险因素及其临床意义研究 |
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| 引用本文： | 包雪青,黄芬,王丽娟,夏捷,王兆洪. 胰腺癌发病的危险因素及其临床意义研究[J]. 中华全科医学, 2023, 21(1): 66-69. DOI: 10.16766/j.cnki.issn.1674-4152.002813 |
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| 作者姓名： | 包雪青 黄芬 王丽娟 夏捷 王兆洪 |
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| 作者单位： | 1.温州医科大学附属第二医院肝胆胰外科, 浙江 温州 325000 |
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| 基金项目： | 浙江省基础公益研究计划项目Q18H290010 |
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| 摘 要： | 目的 收集胰腺癌(PC)患者发病的相关资料，通过统计学方法分析影响PC发病的危险因素，并针对其危险因素采取防治措施。 方法 选取2019年1月—2020年12月在温州医科大学附属第二医院治疗的256例PC患者作为观察组，另选取同期在该院住院治疗的非PC患者256例作为对照组，收集2组患者的相关临床资料，采用单因素分析法和多因素logistic回归分析研究影响PC发病的危险因素，并探讨其临床意义。 结果 单因素分析结果显示观察组男性、伴有糖尿病(DM)、PC家族史、胰腺炎病史、DM家族史以及肥胖的人数比例均明显高于对照组(均P＜0.05)，但观察组中使用二甲双胍治疗的DM患者人数比例明显低于对照组(28.77% vs. 58.97%，P＜0.05)；多因素logistic回归分析显示，伴有DM、DM家族史、PC家族史、胰腺炎病史、肥胖为PC发病的独立危险因素(OR分别为3.251、2.208、2.252、3.373、3.257，95%CI分别为1.383~7.640、1.016~4.797、1.067~4.752、1.279~8.899、1.257~8.443)，二甲双胍是糖尿病患者发生PC的保护因素(OR为0.451，95%CI为0.239~0.853)。 结论 伴有DM、DM家族史、PC家族史、胰腺炎病史、肥胖是PC发病的独立危险因素，临床应对伴有上述危险因素的人群警惕PC的发生，特别是对同时伴有DM家族史、PC家族史、肥胖的DM患者应采取积极防治措施；而二甲双胍能有效降低DM患者发生PC的风险，是DM患者发生PC的保护因素。
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| 关 键 词： | 胰腺癌 糖尿病 二甲双胍 危险因素 临床意义 |
| 收稿时间： | 2022-06-11 |
Risk factors and clinical significance of pancreatic cancer |
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| Affiliation: | Department of Hepatobiliary and Pancreatic Surgery, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China |
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| Abstract: | Objective To collect the data on pancreatic cancer (PC), and to analyze the risk factors for pancreatic cancer, and to develop preventive measures. Methods A total of 256 cases of patients with PC treated in our hospital from January 2019 to December 2020 were selected as the observation group, and a total of 256 cases of patients without PC who were hospitalised in the Second Affiliated Hospital of Wenzhou Medical University during the same period were selected as the control group. Relevant clinical data of the two groups were collected, and the risk factors affecting the incidence of PC were analysed by univariate analysis and multivariate logistic regression. The clinical significance of such data was also explored. Results Univariate analysis showed that the proportion of men, patients with diabetes mellitus (DM), family history of PC, history of pancreatitis, family history of DM and obesity in the observation group were significantly higher than those in the control group (all P < 0.05). But the proportion of patients with DM treated with metformin in the observation group was significantly lower than that in the control group (28.77% vs. 58.97%, P < 0.05). Multivariate logistic regression analysis showed that DM, family history of DM, family history of PC, history of pancreatitis and obesity were independent risk factors for PC (OR were 2.251, 2.208, 2.252, 3.373, 3.257, respectively). 95%CI were 1.383 to 7.640, 1.016 to 4.797, 1.067 to 4.752, 1.279 to 8.899, 1.257 to 8.443, respectively. Metformin was a protective factor for PC in diabetic patients (OR was 0.451, 95%CI was 0.239 to 0.853). Conclusion DM, family history of DM, family history of PC, history of pancreatitis, and obesity are independent risk factors for the development of PC. Patients with these risk factors should be vigilant about the occurrence of PC, especially those with family history of DM, family history of PC, and obesity should take active prevention and treatment measures. Metformin can effectively reduce the risk of PC in DM patients, which is a protective factor for PC in DM patients. |
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