| 基于CD19/IgM亚群分析套细胞淋巴瘤骨髓中T细胞的构比异常 |
| |
| 引用本文： | 胡雯博,唐君玲,李晓明. 基于CD19/IgM亚群分析套细胞淋巴瘤骨髓中T细胞的构比异常[J]. 现代肿瘤医学, 2023, 0(8): 1481-1485. DOI: 10.3969/j.issn.1672-4992.2023.08.017 |
| |
| 作者姓名： | 胡雯博 唐君玲 李晓明 |
| |
| 作者单位： | 西南医科大学附属医院血液内科，四川 泸州 646000 |
| |
| 基金项目： | 泸州市科技局应用基础研究项目（编号:2019LZXNYDJ54）；四川省重点研发项目（编号:2019YFS0301） |
| |
| 摘 要： | 目的:研究T细胞在初诊IV期套细胞淋巴瘤(mantle cell lymphoma, MCL)骨髓单个核细胞中的差异表达。方法:首先流式检测健康供者及MCL组中CD19-/IgM-,CD19-/IgM+,CD19+/IgM-,CD19+/IgM+亚群的比例；其次检测CD45+CD3+T细胞在两组中的总比例；最后检测T细胞在两组四个亚群中的占比。结果:四个亚群在组内有极其显著的差异(P<0.000 1),两组间无统计学差异。T细胞在MCL组占(0.46±0.13)%较健康供者组(1.10±0.06)%显著减少(P=0.025 1)。四个亚群中T细胞占比在健康供者组内有极其显著的差异(P<0.000 1),而MCL组内差异消失(P=0.329 4)。T细胞在MCL组CD19-/IgM-亚组中占(0.02±0.01)%较...
|
| 关 键 词： | T细胞 CD19/IgM亚群 套细胞淋巴瘤 |
The expression characteristics of T cells in mantle cell lymphoma bone marrow based on CD19/IgM sub-populations |
| |
| HU Wenbo,TANG Junling,LI Xiaoming. The expression characteristics of T cells in mantle cell lymphoma bone marrow based on CD19/IgM sub-populations[J]. Journal of Modern Oncology, 2023, 0(8): 1481-1485. DOI: 10.3969/j.issn.1672-4992.2023.08.017 |
| |
| Authors: | HU Wenbo TANG Junling LI Xiaoming |
| |
| Affiliation: | Department of Hematology,the Affiliated Hospital of Southwest Medical University，Sichuan Luzhou 646000，China． |
| |
| Abstract: | Objective:To investigate the differential expression of T cells in bone marrow mononuclear cells of newly diagnosed stage IV mantle cell lymphoma (MCL).Methods:Firstly,the proportions of CD19-/IgM-，CD19-/IgM+，CD19+/IgM-,CD19+/IgM+ sub-populations in healthy donors and MCL group were detected by flow cytometry.Secondly,the total proportion of CD45+CD3+T cells in the two groups was detected.Finally,the ratios of T cells in the four sub-populations of the two groups were detected.Results:There were significant differences among the four sub-populations in each group (P＜0.000 1),and there was no significant difference between the two groups.The percentage of T cells in MCL group (0.46±0.13)% was significantly lower than that in healthy donor group(1.10±0.06)% (P=0.025 1).There was a significant difference in the proportion of T cells among the four sub-populations in the healthy donors group (P＜0.000 1),but such difference wasn' t found in the MCL group (P=0.329 4).The percentage of T cells in the sub-populations of CD19-/IgM- in the MCL group was (0.02±0.01)%,which was lower than that of the healthy donor group (1.51±0.35)% (P＜0.000 1).The percentage of T cells in the sub-population of CD19+/IgM- in healthy donor group and MCL group was (4.28±0.14)% and (0.65±0.45)%,respectively.The ratio of T cells in the sub-population of CD19+/IgM- in MCL group was still significantly decreased (P=0.001 2).There was no statistical difference for the other two subgroups between the two groups.Conclusion:Compared with healthy donors,the total proportion of T cells in bone marrow lesions of newly diagnosed MCL with stage IV was significantly decreased and the percentages of T cells in the sub-populations of CD19-/IgM- and CD19+/IgM-were significantly decreased.It is suggested that the lack of normal number of T cells in the bone marrow lesions of MCL,and leads to weakened immune monitoring,which may promote the occurrence and development of tumors. |
| |
| Keywords: | T cells sub-populations of CD19/IgM mantle cell lymphoma |
|
| 点击此处可从《现代肿瘤医学》浏览原始摘要信息 |
|
点击此处可从《现代肿瘤医学》下载免费的PDF全文 |
|
