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《现代肿瘤医学》[ISSN:1672-4992/CN:61-1415/R]

期数:

2023年04期

页码:

733-736

栏目:

论著（血液系统肿瘤）

出版日期:

2023-01-12

文章信息/Info

Title:

Correlation between the cytokine levels before and after chemotherapy and involved chemotherapy-induced cognitive impairment in non-Hodgkin' s lymphoma patients

作者:

李皓吾; 程怀东; 轩 菡

安徽医科大学第二附属医院肿瘤科，安徽 合肥 230000

Author(s):

LI Haowu; CHENG Huaidong; XUAN Han

Department of Oncology,the Second Affiliated Hospital of Anhui Medical University，Anhui Hefei 230000,China.

关键词:

非霍奇金淋巴瘤; 化疗相关认知障碍; 细胞因子; 卡氏功能状态评分

Keywords:

non-Hodgkin's lymphoma; chemotherapy-induced cognitive impairment; cytokines; KPS

分类号:

R733.4

DOI:

10.3969/j.issn.1672-4992.2023.04.026

文献标识码:

A

摘要:

目的：研究非霍奇金淋巴瘤（non-Hodgkin's lymphoma,NHL）患者在化疗前后细胞因子水平与认知功能发生的变化，明确细胞因子、功能状况与认知功能之间的关联性。方法：共纳入30名NHL患者，受试者在化疗前和进行2程化疗后完成全面的心理学量表及细胞因子白细胞介素4（interleukin 4，IL-4）与白细胞介素6（interleukin 6，IL-6）评估。结果:受试者的IL-4水平在治疗前比治疗后高（t=2.85,P<0.01），而IL-6水平在治疗前比治疗后低（P<0.01）。IL-6与前瞻性记忆（prospective memory,PM）、回顾性记忆（retrospective memory,RM）之间具有弱相关(r=0.282、0.270，P均<0.05)，IL-6与日常认知量表（ECog-12）之间具有中度相关(r=0.314，P<0.05)。IL-4与认知之间未发现相关性。简易精神检查量表（mini-mental state examination,MMSE）、言流畅性测试（verbal fluency test,VFT）、符号数字模式测验（symbol digit modalities test,SDMT）、 画钟测试（clock drowing test,CDT）、 RM和 卡氏评分（karnofsky performance status,KPS）之间均有中度相关(r=0.479、0.378、 0.464、 0.396、-0.366，P均<0.01)。结论:NHL患者的认知功能在化疗后短期时间受到损伤，表现在视空间障碍、语言及记忆方面。IL-4可能是认知功能的保护因素，而IL-6可能是认知功能的损伤因素。NHL认知功能的管理及改善将有助于提高KPS水平，从而提高患者的生存质量与对化疗的耐受程度。

Abstract:

Objective:To investigate,the changes of cytokine levels and cognitive function in patients with non-Hodgkin's lymphoma(NHL)before and after chemotherapy to clarify the correlation between cytokines,functional status and cognitive function.Methods:A total of 30 patients with NHL were included in this study.These patients completed cognitive assessment and cytokine levels which including interleukin 4（IL-4） and interleukin 6（IL-6） before chemotherapy and after 2 courses of chemotherapy.Results:The IL-4 level of patients was higher before treatment than after treatment（t=2.85,P<0.01）,and IL-6 level was lower before treatment than after treatment（P<0.01）.IL-6 had a weak correlation with retrospective memory(RM) and prospective memory(PM)(r=0.282 and 0.270,respectively,all P<0.05).There was a moderate correlation between IL-6 and ECog-12(r=0.314,P<0.05),but no statistical association was found between cognition and IL-4.There was a moderate correlation between subjects' cognition(MMSE,VFT,SDMT,CDT,RM)and KPS(r=0.479,0.378,0.464,0.396 and-0.366,respectively,all P<0.01).Conclusion:The cognitive function of NHL patients is impaired in a short time after chemotherapy,which is manifested in visuospatial disturbance,language and memory.IL-4 may be a protective factor of cognitive function,and IL-6 may be a factor of impairment of cognitive function.Management and improvement of cognitive function in NHL will help to improve KPS levels.

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备注/Memo

备注/Memo:

National Natural Science Foundation of China(No.81872504);国家自然科学基金资助项目（编号：81872504）

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更新日期/Last Update: 1900-01-01