| 先天自愈性朗格汉斯组织细胞增生症一例 |
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| 引用本文： | 王娜,吴梅,周桂芝,杨青. 先天自愈性朗格汉斯组织细胞增生症一例[J]. 中国麻风皮肤病杂志, 2023, 39(1): 37-39. DOI: 10.12144/zgmfskin202301037 |
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| 作者姓名： | 王娜 吴梅 周桂芝 杨青 |
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| 作者单位： | 山东第一医科大学附属皮肤病医院（山东省皮肤病医院），山东省皮肤病性病防治研究所，济南，250022 |
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| 摘 要： | 患儿，女，1个月。头面部红色丘疹、结痂，逐渐增多1个月。皮肤科查体：头皮、额头、躯干、四肢散在黄豆至豌豆大红褐色至黄褐色丘疹、丘疱疹、结痂，部分皮疹少量鳞屑，不易刮除。皮损组织病理示：表皮细胞间水肿，单一核细胞移入，基底细胞液化变性，真皮浅中层较多单一核细胞浸润，细胞核大、胞浆丰富。DIF:表皮细胞间及基底膜带IgG、C3、IgM、IgA阴性。免疫组化：CD1a、S100、CD68弱阳性，Langerin+。未予治疗，随访1个月皮疹基本消退，无新发皮疹。
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| 关 键 词： | 朗格汉斯组织细胞增生症 自愈性 先天性 |
Congenital self-healing Langerhans cell histiocytosis: a case report |
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| WANG Na,WU Mei,ZHOU Guizhi,YANG Qing. Congenital self-healing Langerhans cell histiocytosis: a case report[J]. China Journal of Leprosy and Skin Diseases, 2023, 39(1): 37-39. DOI: 10.12144/zgmfskin202301037 |
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| Authors: | WANG Na WU Mei ZHOU Guizhi YANG Qing |
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| Affiliation: | Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250022, China |
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| Abstract: | A one-month-old girl presented with red papules and scabs on her head and face gradually increased for 1 month. Dermatological examination showed soybean to pea sized papules, papulovesicles, scabs on his scalp, forehead, trunk and limbs. A few of the rashes have scales, which were not easily to scrape. Histopathological examination revealed edema between epidermal cells, mononuclear cell migration, basal cell liquefaction and degeneration, more mononuclear cell infiltration in the superficial and middle dermis, with large nucleus and rich cytoplasm. DIF: negative for IgG, C3, IgM, IgA between epidermal cells and basement membrane. Immunohistochemistry: weakly positive for CD1a, S100, CD68, positive for Langerin. No treatment was given. The lesions dissipated and no new rash occurred after 1 month follow-up. |
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| Keywords: | Langerhans cell histiocytosis self-healing congenital |
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