Comparison of ceftazidime concentrations in bile and serum. |
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| Authors: | E Bouza, T Hellí n, M Rodrí guez-Creixems, J Martí nez-Beltr n, E Loza, F Baquero |
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| Affiliation: | E Bouza, T Hellín, M Rodríguez-Creixems, J Martínez-Beltrán, E Loza, and F Baquero |
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| Abstract: | Biliary excretion of ceftazidime, a new broad-spectrum cephalosporin, was studied in two groups of patients after administration of a 2-g dose intravenously. Group A included 10 patients in whom ceftazidime levels in bile were measured during cholecystectomy. Group B included 10 patients with indwelling biliary tubes in whom ceftazidime levels in bile and serum were simultaneously measured at 0.5, 1, 2, 4, 6, and 8 h after administration of the drug. Although ceftazidime levels were variable, they exceeded the minimal inhibitory concentrations of most biliary tract pathogens in both groups. |
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