Proteomic analysis of azole resistance in Candida albicans clinical isolates |
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| Authors: | Hooshdaran Massoumeh Z Barker Katherine S Hilliard George M Kusch Harald Morschhäuser Joachim Rogers P David |
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| Affiliation: | Department of Pharmacy, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA. |
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| Abstract: | Changes in protein expression within a matched set of Candida albicans isolates representing the acquisition of azole resistance were examined by two-dimensional polyacrylamide gel electrophoresis and peptide mass fingerprinting. Proteins differentially expressed in association with azole resistance included Grp2p, Ifd1p, Ifd4p, Ifd5p, and Erg10p, a protein involved in the ergosterol biosynthesis pathway. |
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