| 子宫颈上皮内病变及子宫颈癌患者外周血及局部免疫功能分析#br# |
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| 引用本文： | 张柏辉 曹志星 陈仁柳 汪丽娟 郑巧丽. 子宫颈上皮内病变及子宫颈癌患者外周血及局部免疫功能分析#br#[J]. 中国妇产科临床杂志, 2021, 23(2): 135. DOI: 10.13390/j.issn.1672-1861.2022.02.007 |
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| 作者姓名： | 张柏辉 曹志星 陈仁柳 汪丽娟 郑巧丽 |
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| 作者单位： | 珠海市人民医院病理科 |
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| 摘 要： | ![]()
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| 关 键 词： | 子宫颈上皮内病变 肿瘤微环境 T细胞亚群 免疫功能 |
Analysis of the peripheral blood and local immune function in patients with cervical lesions and cervical cancer |
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| ZHANG Bohui,CAO Zhixing,CHEN Renliu,WANG Lijian,ZHENG Qiaoli. Analysis of the peripheral blood and local immune function in patients with cervical lesions and cervical cancer[J]. Chinese Journal of Clinical Obstetrics and Gynecology, 2021, 23(2): 135. DOI: 10.13390/j.issn.1672-1861.2022.02.007 |
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| Authors: | ZHANG Bohui CAO Zhixing CHEN Renliu WANG Lijian ZHENG Qiaoli |
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| Abstract: | ![]()
Objective?To investigate the distribution of T cell subsets in peripheral blood of different cervical lesions and the level of cytokines secreted, and it’s difference in the location and density of immune cell distribution in the epithelium and stroma of cervical lesion tissues. Methods?We used CD series cell detection slide quality control kit to detect the distribution of T cell subsets in peripheral blood of 55 patients with different cervical lesions, analyzed the changes of peripheral blood cytokines, and analyzed the localization and density distribution of T lymphocytes (CD4+T, CD8 +T) in the tissue microenvironment of 64 patients with different cervical lesions by immunohistochemistry. Results?The level of CD4+T and CD8+T in peripheral blood of patients with low grade lesion (LSIL) were lower, with 479.13±229.65 unit and 378.00±231.74 unit respectively. The level of CD4+T and CD8+T in high grade cervical squamous intraepithelial lesion(HSIL)was 816.30±284.65 unit and 668.75±268.92 unit respectively, and the level of CD4+T and CD8+T in carcinoma was 824.80±330.65 unit and 564.00±58.31 unit. Meanwhile the concentration of IL-17 in the serum of LSIL patients was higher than that of HSIL (P<0.05). CD8+T cells in epithelial and stroma tissues of cervical cancer were higher than those in control, LSIL and HSIL tissues, with statistical significance (P<0.05). However, CD4+T cells in the stroma of cancer tissues were higher than those of control, LSIL and HSIL tissues, with statistical significance (P<0.001). Conclusion?The patients with cervical lesion have abnormal immune function in the systemic immunity and local microenvironment of the lesion, both CD8+T cells and CD4+T cells play a key role in eliminating HPV-infected cervical epithelial cells. The development of cervical lesions is related to the cellular inflammatory factors. |
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| Keywords: | cervical lesions microenvironment T cell subset immune function |
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