| 国产吉西他滨联合卡铂治疗晚期非小细胞肺癌近期临床观察 |
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| 引用本文： | 牛红蕊, 崔艳慧, 刘晶, 寇小格, 路平. 国产吉西他滨联合卡铂治疗晚期非小细胞肺癌近期临床观察[J]. 中国肿瘤临床, 2007, 34(15): 857-859. |
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| 作者姓名： | 牛红蕊 崔艳慧 刘晶 寇小格 路平 |
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| 作者单位： | 新乡医学院第一附属医院肿瘤科, 河南省新乡市 453100 |
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| 摘 要： | 目的:观察国产吉西他滨联合卡铂治疗晚期非小细胞肺癌临床疗效及不良反应。方法:154例晚期非小细胞肺癌患者随机分为两组,观察组76例,给予GC方案(吉西他滨联合卡铂),21天为1周期。对照组78例,给予EP方案(足叶乙甙联合顺铂),21天为1周期。均至少化疗2周期。结果:154例患者均可评价疗效和不良反应,观察组疗效明显优于对照组(47.4%Vs25.6%,P<0.05),主要不良反应为白细胞下降、胃肠道反应,均较对照组轻,腹泻较对照组稍重,其他不良反应两组相似均可耐受。结论:吉西他滨联合卡铂治疗晚期非小细胞肺癌近期临床疗效较高,不良反应可以耐受。
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| 关 键 词： | 吉西他滨 卡铂 联合化疗 非小细胞肺癌 |
| 收稿时间： | 2006-12-20 |
| 修稿时间： | 2006-12-20 |
Clinical Investigation of Gemcitabine Treatment with Carboplatin for Advanced Non-small Cell Lung Cancer |
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| Niu Hongrui, Cui Yanhui, Liu Jing et al, . Clinical Investigation of Gemcitabine Treatment with Carboplatin for Advanced Non-small Cell Lung Cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2007, 34(15): 857-859. |
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| Authors: | Niu Hongrui Cui Yanhui Liu Jing et al |
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| Affiliation: | Department of Oncology, the First Affiliated Hospital of Xinxiang Medical College, Urumqi |
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| Abstract: | Objectives: To evaluate the efficacy and adverse effects of gemcitabine with carbo-platin in the treatment of advanced non-small cell lung cancer. Methods: One hundred fifty-four pa-tients with advanced non-small cell lung cancer were randomly divided two groups. Seventy-six casesin the experimental group were treated with Gemcitabine combined with carboplatin. This treatment was repeated once every three weeks. Seventy-eight cases in the control group were treated with VP- 16 combined with Cisplatin. This treatment was also repeated once every three weeks. Results: All patients completed the treatment schedule. The overall response rate (CR+PR) in the experimental group was significantly higher than that in the control group: 47.4% vs. 25.6%(P<0.05). The main toxicities re-ported were well tolerated. Leukopenia and nausea/vomiting in grade Ⅲ+IV occurred more frequently in the control group than in the observation group(P<0.05), and there were no significant differences be-tween the two groups in the other acute toxicities reported (P>0.05). Conclusion: Gemcitabine com-bined with carboplatin showed a better therapeutic effect in the treatment of advanced non- small celllung cancer, and the adverse effects were mild and well- tolerated. |
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| Keywords: | gemeilabine ehemotherapy non-small cell lung cancer |
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