| 安庆市新生儿先天性甲状腺功能减退症TSH筛查切值探讨 |
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| 引用本文： | 陈实庆,陈军,邓虹,王良秀,赵敬智,刘浩,俞宝圣,吴珍珍,余佳,吴芳. 安庆市新生儿先天性甲状腺功能减退症TSH筛查切值探讨[J]. 中国儿童保健杂志, 2016, 24(2): 217-218. DOI: 10.11852/zgetbjzz2016-24-02-32 |
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| 作者姓名： | 陈实庆 陈军 邓虹 王良秀 赵敬智 刘浩 俞宝圣 吴珍珍 余佳 吴芳 |
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| 作者单位： | 安庆市妇幼保健所新生儿疾病筛查中心,安徽 安庆 246004 |
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| 基金项目： | 2014年安徽省卫生计生委科研计划项目(14FR011) |
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| 摘 要： | 目的 探讨制定合理的本地新生儿促甲状腺素(TSH)筛查切值。方法 对本市59 295例新生儿TSH筛查结果进行分析,使用百分位数法及ROC曲线法制定TSH筛查切值。结果 新生儿TSH水平呈偏态分布,P25为1.47 mU/L,P50为2.52 mU/L,P75为3.96 mU/L,P95为6.89 mU/L ,P99为8.94 mU/L;ROC曲线法得出本实验室TSH筛查切值为8.12 mU/L。按ROC筛查切值诊断22例先天性甲状腺功能减退症(CH)和28例高TSH血症,若按P99和试剂盒给定的切值标准将漏诊CH患儿1例,漏诊率达4.55%。结论 选用ROC曲线法确定适宜的TSH切值是提高原发性先天性甲状腺功能减退症筛查质量的重要措施。
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| 关 键 词： | 先天性甲状腺功能减退症 促甲状腺素 筛查 ROC曲线 切值 |
| 收稿时间： | 2015-07-02 |
Study on screening cut-off points of the thyroid-stimulating hormone in Anqing |
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| CHEN Shi-qing,CHEN Jun,DENG Hong,WANG Liang-xiu,ZHAO Jing-zhi,LIU Hao,YU Bao-sheng,WU Zhen-zhen,YU Jia,WU Fang. Study on screening cut-off points of the thyroid-stimulating hormone in Anqing[J]. Chinese Journal of Child Health Care, 2016, 24(2): 217-218. DOI: 10.11852/zgetbjzz2016-24-02-32 |
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| Authors: | CHEN Shi-qing CHEN Jun DENG Hong WANG Liang-xiu ZHAO Jing-zhi LIU Hao YU Bao-sheng WU Zhen-zhen YU Jia WU Fang |
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| Affiliation: | Maternal and Child Health Care Hospital of Anqing,Anqing,Anhui 246004,China |
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| Abstract: | Objective To know the distribution of TSH and incidence of neonatal congenital hypothyroidism(CH),and study the screening cut-off points of the thyroid-stimulating hormone(TSH)in Anqing. Methods The neonatal screening data about 59 295 newborns in Anqing were analyzed and the TSH cut-off points were calculated by method of percentiles and Receiver Operating Characteristic (ROC)curve,then,the incidence of sufferers was analyzed by different cut-off points. Results The distribution of the neonatal screening data was deflection,P50 was 2.52 mU/L,P99 was 8.94 mU/L.Combined with ROC curve,the cut-off points of our lab was 8.12 mU/L. Conclusions Different cut-off points effect the consequences of the neonatal screening.It is important to establish the suitable cut-off points with ROC curve based on lab. |
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| Keywords: | congenital hypothyroidism thyrotropic-stimulating hormone neonatal screening ROC curve cut-off points |
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