| 子宫内膜癌患者miR-30b和miR-96水平及与预后的关系 |
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| 引用本文： | 林一禾,庄晓苹,金纬纬. 子宫内膜癌患者miR-30b和miR-96水平及与预后的关系[J]. 中华全科医学, 2021, 19(1): 73-76,107. DOI: 10.16766/j.cnki.issn.1674-4152.001734 |
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| 作者姓名： | 林一禾 庄晓苹 金纬纬 |
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| 作者单位： | 温州市中西医结合医院西医妇科，浙江 温州 325000 |
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| 基金项目： | 浙江省医药卫生科技计划项目(2017KY630)。 |
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| 摘 要： | 目的 检测子宫内膜癌(endometrial cancer,EC)患者外周血单个核细胞(peripheral blood mononuclear cell,PBMC)miR-30b、miR-96水平,探究其与临床病理及预后的关系.方法 选择2012年10月-2014年8月温州市中西医结合医院收治的EC患者及门诊健康体检...
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| 关 键 词： | 子宫内膜癌 微小RNA-30b 微小RNA-96 |
| 收稿时间： | 2019-09-09 |
Expression of miR-30b and miR-96 in endometrial carcinoma and their relationship with prognosis |
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| LIN Yi-he,ZHUANG Xiao-ping,JIN Wei-wei. Expression of miR-30b and miR-96 in endometrial carcinoma and their relationship with prognosis[J]. Applied Journal Of General Practice, 2021, 19(1): 73-76,107. DOI: 10.16766/j.cnki.issn.1674-4152.001734 |
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| Authors: | LIN Yi-he ZHUANG Xiao-ping JIN Wei-wei |
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| Affiliation: | Western medicine gynecology of Western medicine Wenzhou integrated Chinese and Western medicine hospital, Wenzhou, Zhejiang 325000, China |
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| Abstract: | Objective The levels of miR-30 b and miR-96 in peripheral blood mononuclear cells(PBMC)in patients with endometrial carcinoma(EC)were detected to explore their relationship with clinicopathology and prognosis.Methods A total of 76 EC patients and healthy outpatients(control group)admitted to Wenzhou hospital of integrated traditional Chinese and western medicine were selected.The expression levels of miR-30 b and miR-96 in PBMC were detected by fluorescence quantitative PCR,the correlation was analyzed by Pearson method,the relationships between miR-30 b and miR-96 expression levels in PBMC and 5-year survival rate of EC patients were analyzed by Kaplan-Meier method,and the risk factors affecting the prognosis of EC patients were analyzed by Cox regression.Results The expression levels of miR-30 b and miR-96 in PBMC of EC patients were higher than those of control group(t=21.913,24.188,all P<0.05).They were positively correlated(r=0.553,P<0.05),and correlated with pathological grade,FIGO stage,depth of muscle invasion and lymph node metastasis(P<0.05).The 5-year overall survival rate of patients with high expression of miR-30 b(16.13%)was lower than that of patients with low expression(66.67%,χ2=16.890,P<0.05).The 5-year overall survival rate of patients with high expression of miR-96(18.18%)was lower than that of patients with low expression(67.44%,χ2=16.307,P<0.05).Levels of miR-30 b and miR-96,FIGO stage and lymph node metastasis in PMBC were independent risk factors affecting the prognosis of EC patients(HR=2.861,95%CI:1.427-5.736;HR=1.973,95%CI:1.462-2.663;HR=2.235,95%CI:1.491-3.350;HR=2.439,95%CI:1.365-4.358;all P<0.05).Conclusion The miR-30 b and miR-96 are highly expressed in PMBC,which are related to pathological grade,FIGO stage,muscle invasion,lymph node metastasis and 5-year survival rate of EC patients,and are independent risk factors for adverse prognosis of EC patients. |
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| Keywords: | Endometrial cancer MicroRNA-30b MicroRNA-96 |
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