Effects of Xianzhen tablet on Na+ - K+ - ATPase and Ca2+ - Mg2+ - ATPase in erythrocytic membranes and viscosity of whole blood in non-insulin-dependent diabetes patients with Qi-Yin deficiency, Kidney deficiency and blood stasis |
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| Authors: | Pan Mingzheng Guo Saishan Liang Xiaochun Chen Xiangyin Xi Pinxiang Wang Xiangding Tian Guoqing Zhang Kejian Shen Tao |
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| Affiliation: | (1) Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, PUMC, 100730 Beijing;(2) Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, PUMC, Beijing |
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| Abstract: | Objective: To assess the effects of Xianzhen tablet (XZT) on Na+-K+-ATPase and Ca2+-Mg2+-ATPase on erythrocytic membranes, viscosity of whole blood, plasma glucose and clinical manifestations.Methods: Seventy-two cases of non-insulin-dependent diabetes mellitus (NIDDM) patients with deficiency of both Qi and Yin, deficiency of the Kidney and blood stasis were selected, and the effects of treatment on Na+ K+ -ATPase, Ca2+-Mg2+-ATPase, whole blood viscosity, blood sugar and clinical symptoms were observed.Results: In XZT group (test group), activities of Na+ -K+ -ATPase and Ca2+ -Mg2+ -ATPase rose significantly (P < 0.01,P < 0.05) after treatment. Viscosity of whole blood and clinical manifestations also improved obviously. The total effective rate in lowering plasma glucose was 77.8% with fasting blood glucose (FBG) and 69. 4% with 2 hours postprandial plasma blood glucose (2°PBG). In the control group, viscosity of whole blood and clinical manifestations had no significant improvement. Its total effective rate in lowering plasma glucose was 41.7% with FBG and 38.9% with 2°PBG.Conclusions: XZT played a certain role in increasing activities of Na+ -K+ -ATPase and Ca2+ -Mg2+ -ATPase, decreasing viscosity of whole blood and plasma glucose and improving clinical manifestations. Therefore, XZT was experimentally manifested as an effective drug in treating NIDDM patients with Qi-Yin deficiency, renal deficiency and blood stasis. |
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| Keywords: | non-insulin-dependent diabetes mellitus erythrocytic membrane Na+ -K+-ATPase Ca2+-Mg2+ -ATPase viscosity of whole blood |
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