Chemical Composition and Antioxidant,Antinociceptive, and Anti‐inflammatory Activities of Four Amazonian Byrsonima Species |
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| Authors: | Fernanda Guilhon‐Simplicio Tallita Marques Machado Leandro Flores do Nascimento Rayanne da Silva Souza Hector Henrique Ferreira Koolen Felipe Moura Araújo da Silva Leonard Domingo Rosales Acho Adair Roberto Soares dos Santos Paul Cos Maria de Meneses Pereira Emerson Silva Lima |
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| Affiliation: | 1. Faculty of Pharmaceutical Sciences, Federal University of Amazonas, Manaus, Amazonas, Brazil;2. Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil;3. Metabolomics and Mass Spectrometry Research Group, Amazonas State University, Manaus, Amazonas, Brazil;4. Department of Chemistry, Federal University of Amazonas, Manaus, Amazonas, Brazil;5. Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium |
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| Abstract: | Species of the Byrsonima genus are widely used in Brazil, especially for the treatment of gastrointestinal disorders. However, species from the Amazonian region are still poorly studied. Thus, we studied the antioxidant, antinociceptive, and anti‐inflammatory activities of for Amazonian species, Byrsonima crispa , Byrsonima duckeana , Byrsonima garcibarrigae , and Byrsonima incarnata . Phenolic composition was determined by chemical and chromatographic methods. The aqueous extracts were evaluated in DPPH?, ABTS+?, and superoxide (O2??) tests, LPS‐activated macrophage assay, and formalin test. All species contained a high phenolic and flavonoid content. We identified 15 phenolic compounds, including phenolic acids, hydroxycinnamic acids, flavonoids, and catechins. The extracts showed high antioxidant activity and were more active than quercetin at inhibiting nitric oxide release in the LPS‐activated macrophage assay. B. duckeana and B. garcibarrigae showed higher in vivo antinociceptive and anti‐inflammatory activities. B. garcibarrigae presented significant effect on the early phase of the formalin test, pointing to an antinociceptive mechanism distinct from traditional anti‐inflammatory medicines. In conclusion, the pharmacological potential of these species is closely related to their flavonoid‐rich chemical composition, which seems to act through antioxidant mechanisms. Copyright © 2017 John Wiley & Sons, Ltd. |
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| Keywords: | Byrsonima flavonoids antioxidant activity antinociceptive activity |
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