Severe excessive daytime sleepiness induced by hydroxyurea |
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| Authors: | Bruno Revol Marie Joyeux‐Faure Marie‐Victoire Albahary Remy Gressin Michel Mallaret Jean‐Louis Pepin Sandrine H. Launois |
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| Affiliation: | 1. HP2, INSERM U1042, Grenoble Alps University, Grenoble Cedex 9, France;2. Pharmacovigilance, Grenoble Alps University Hospital, Grenoble Cedex 9, France;3. Thorax and Vessels, EFCR, Grenoble Alps University Hospital, Grenoble Cedex 9, France;4. IAB, INSERM U1209, CNRS UMR 5309, Grenoble Alps University, Grenoble Cedex 9, France;5. Hematology, Grenoble Alps University Hospital, Grenoble Cedex 9, France;6. UPMC Paris 6, INSERM UMRS 1158, Sorbonne University, Paris, France;7. St Antoine Hospital, GHUEP, Paris, France |
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| Abstract: | Excessive daytime sleepiness (EDS) has been reported with many drugs, either as an extension of a hypnotic effect (e.g. central nervous system depressants) or as an idiosyncratic response of the patient. Here, we report unexpected and severe subjective and objective EDS induced by hydroxyurea therapy, with a favorable outcome after withdrawal. Clinical history, sleep log, polysomnography, and multiple sleep latency tests confirming the absence of other EDS causes are presented. |
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| Keywords: | excessive daytime sleepiness hydroxyurea unexpected adverse drug reaction |
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