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| 组织因子和基质金属蛋白酶-9在乳腺癌中的表达与预后分析 | |
| 引用本文： | 赵建新, 林增茂, 姚宏伟, 万远廉. 组织因子和基质金属蛋白酶-9在乳腺癌中的表达与预后分析[J]. 中国肿瘤临床, 2008, 35(1): 22-25. |
| 作者姓名： | 赵建新 林增茂 姚宏伟 万远廉 |
| 作者单位： | 1.北京大学第一医院普通外科, 北京市 100034;;2.北京大学第三医院 |
| 基金项目： | 国家自然科学基金资助（编号：30471683） |
| 摘 要： | 目的: 研究乳腺癌组织中组织因子(tissuefactor,TF)和基质金属蛋白酶-9(matrixmetalloproteinase-9,MMP-9)的表达并分析其阳性表达与预后的关系。 方法: 应用二步法(EnVision)免疫组化方法检测71例乳腺癌组织中TF和MMP-9的表达情况并分析其随访资料。 结果: TF和MMP-9在71例乳腺癌组织中染色阳性率分别为43.7%和42.3%。K-M法单因素分析显示其阳性表达患者的5年生存率低于阴性患者(P<0.05)。COX多因素分析提示TNM分期、淋巴结转移是乳腺癌的预后因子,而TF、MMP-9不能作为独立预后因子(P>0.05)。 结论: TF和MMP-9在乳腺癌组织中的阳性表达率较高,对判断患者的预后有一定的作用。 |
| 关 键 词： | 乳腺癌 基质金属蛋白酶 组织因子 免疫组织化学 预后 |
| 收稿时间： | 2007-07-03 |
| 修稿时间： | 2007-12-01 |
The Expression of Transferrin and MMP-9 in Breast Cancer and Its Significance in Prognosis |
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| ZHAO Jianxin, LIN Zengmao, YAO Hongwei, WAN Yuanlian. The Expression of Transferrin and MMP-9 in Breast Cancer and Its Significance in Prognosis[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2008, 35(1): 22-25. | |
| Authors: | ZHAO Jianxin LIN Zengmao YAO Hongwei WAN Yuanlian |
| Affiliation: | 1.Department of General Surgery, The First Hospital of Peking University, Beijing 100034, China;;2.The Third Hospital of Peking University, Beijing China |
| Abstract: | Objective: To detect the expression of transferrin (TF) and MMP-9 in breast cancer and to investigate its significance in prognosis. Methods: The expression of TF and MMP-9 in 71 breast cancer specimens was detected by EnVision immunohistochemistry. Results: The positive expression rate of TF and MMP-9 was 43.7% and 42.3%, respectively. Kaplan-Meier survival curves showed that the 5-year survival rate of the patients with positive expression of TF and MMP-9 was lower than that of the patients with negative expression of TF and MMP-9(P<0.05). However, multivariate analysis showed that TNM-staging and lymph node metastasis were significant prognostic factors, and the expression of TF and MMP-9 were not independent prognostic factors (P>0.05). Conclusion: The positive rate of TF and MMP-9 expression was high in breast cancer tissues. TF and MMP-9 expression levels might be able to provide prognostic information. |
| Keywords: | Breast cancer MMP-9, TF Immunohistochemistry Prognosis |
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