Analysis of Ha-ras 1 allele frequencies in hereditary non-polyposis colorectal cancer. |
| |
| Authors: | P Jeevaratnam P J Browett N S Van de Water J R Jass |
| |
| Affiliation: | Department of Molecular Medicine and Pathology, School of Medicine, University of Auckland, New Zealand. |
| |
| Abstract: | Restriction enzyme digests of genomic DNA show multiple alleles of common, intermediate, and rare frequencies at the minisatellite locus of Ha-ras. It has been suggested that a higher frequency of rare alleles is associated with the presence of colorectal and other types of cancer. This study investigated the distribution of Ha-ras alleles in 40 members of hereditary non-polyposis colorectal carcinoma (HNPCC) families and in 34 cancer free subjects (spouses). There was no difference in rare allele frequency between the cancer group and cancer free group (chi2 = 0.25, not significant). |
| |
| Keywords: | |
|
|
