Cationic gadolinium chelate for magnetic resonance imaging of cartilaginous defects |
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| Authors: | Kido Nwe Ching‐Hui Huang Feini Qu Robert Warden‐Rothman Clare Y. Zhang Robert L. Mauck Andrew Tsourkas |
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| Affiliation: | 1. Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA;2. School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA;3. Department of Radiology, Coatesville Veterans Affairs Medical Center, Coatesville, PA, USA;4. Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA |
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| Abstract: | The ability to detect meniscus defects by magnetic resonance arthrography (MRA) can be highly variable. To improve the delineation of fine tears, we synthesized a cationic gadolinium complex, (Gd‐DOTA‐AM4)2+, that can electrostatically interact with Glycosaminoglycans (GAGs). The complex has a longitudinal relaxivity (r1) of 4.2 mM‐1s‐1 and is highly stable in serum. Its efficacy in highlighting soft tissue tears was evaluated in comparison to a clinically employed contrast agent (Magnevist) using explants obtained from adult bovine menisci. In all cases, Gd‐DOTA‐AM4 appeared to improve the ability to detect the soft tissue defect by providing increased signal intensity along the length of the tear. Magnevist shows a strong signal near the liquid‐meniscus interface, but much less contrast is observed within the defect at greater depths. This provides initial evidence that cationic contrast agents can be used to improve the diagnostic accuracy of MRA. Copyright © 2016 John Wiley & Sons, Ltd. |
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| Keywords: | gadolinium MRA magnetic resonance arthrography imaging chelate DOTA magenevist cationic |
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