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| 伊立替康联合替吉奥二线治疗晚期胃癌的临床观察 | |
| 引用本文： | 常青. 伊立替康联合替吉奥二线治疗晚期胃癌的临床观察[J]. 现代肿瘤医学, 2016, 0(14): 2254-2256. DOI: 10.3969/j.issn.1672-4992.2016.14.023 |
| 作者姓名： | 常青 |
| 作者单位： | 沛县人民医院肿瘤内科，江苏 徐州 221600 |
| 摘 要： | 目的:观察伊立替康联合替吉奥二线治疗晚期胃癌的疗效和毒副反应。方法:53例晚期胃癌给予伊立替康180mg/m2，静脉滴注，d1；替吉奥60mg/m2，口服，分2次/d，第d1~14，21d为1个周期。至少治疗2个周期。结果:50例可评价疗效，其中CR 4例，PR 17例，SD 15例，PD 14例，总有效率为42%，疾病控制率72%。常见毒副反应为中性粒细胞减少、迟发性腹泻、恶心、呕吐等，多为Ⅰ-Ⅱ度。结论:伊立替康联合替吉奥二线治疗晚期胃癌疗效较好，毒副反应可耐受。 |
| 关 键 词： | 伊立替康 替吉奥 晚期胃癌 |
The effect of irinotecan combined with TS - 1 in the treatment of advanced gastric cancer as second - line chemotherapy regimen |
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| Chang Qing. The effect of irinotecan combined with TS - 1 in the treatment of advanced gastric cancer as second - line chemotherapy regimen[J]. Journal of Modern Oncology, 2016, 0(14): 2254-2256. DOI: 10.3969/j.issn.1672-4992.2016.14.023 | |
| Authors: | Chang Qing |
| Affiliation: | Department of Medical Oncology,The People's Hospital of Pei County,Jiangsu Xuzhou 221600，China. |
| Abstract: | Objectlve:To observe the efficacy and toxicities of irinotecan combined with TS - 1 in the treatment of advanced gastric cancer as second - line regimen. Methods:All 53 cases with advanced gastric cancer received chem-otherapy. The remigen:Irinotecan 180mg/ m2 ,intravenous drip,d1;TS - 1 60mg/ m2 take orally,twice daily,d1 ~ 14 . 21 days was 1 cycle,two cycles were given at least. Results:In 50 evaluable cases,CR were observed in 4 cases,PR 17 cases,SD 15 cases,PD 14 cases,the overall response rate was 42% ,the disease control rate was 72% . The main tox-icities were neutropenia,delayed diarrhea,nausea,vomiting,most of them were degree Ⅰ - Ⅱ. Conclusion:Irinote-can combined with TS - 1 as second - line regimen is efficacious,and the toxicities are tolerated for advanced gastric cancer. |
| Keywords: | irinotecan TS - 1 advanced gastric cancer |
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