| 毛发鼻指(趾)综合征-1基因与肿瘤关系的研究进展 |
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| 引用本文： | 赵佳,宋雨霖,张玉霞,孙滨州,王晶. 毛发鼻指(趾)综合征-1基因与肿瘤关系的研究进展[J]. 实用肿瘤学杂志, 2015, 29(1): 78-81. DOI: 10.11904/j.issn.1002-3070.2015.01.017 |
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| 作者姓名： | 赵佳 宋雨霖 张玉霞 孙滨州 王晶 |
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| 作者单位： | 哈尔滨医科大学附属肿瘤医院妇科(哈尔滨 150081) |
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| 摘 要： | 毛发鼻指(趾)综合征-1基因(TRPS1)是GATA转录因子家族成员之一,在多种组织中广泛表达,在调节细胞的增殖分化和组织的生长发育中发挥重要作用。TRPS1基因缺失可导致毛发鼻指(趾)综合征。近年来研究发现,TRPS1在乳腺癌、前列腺癌、骨肉瘤等多种肿瘤组织中异常表达,并且与肿瘤的发生、淋巴结转移、病理分级和临床分期有关。因此,TRPS1被认为是一种潜在的抑癌因子,其表达异常可能是导致肿瘤发生和发展的作用机制之一。本综述将阐述TRPS1基因在肿瘤发生发展中的研究进展,为肿瘤的临床诊断和预测肿瘤患者预后提供一个新的参考指标。
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| 收稿时间： | 2014-10-23 |
The research progression on the relationship between TRPS1 and tumors |
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| ZHAO Jia,SONG Yulin,ZHANG Yuxia,SUN Binzhou,WANG Jing. The research progression on the relationship between TRPS1 and tumors[J]. Journal of Practical Oncology, 2015, 29(1): 78-81. DOI: 10.11904/j.issn.1002-3070.2015.01.017 |
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| Authors: | ZHAO Jia SONG Yulin ZHANG Yuxia SUN Binzhou WANG Jing |
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| Affiliation: | Department of Gynecology,The Affiliated Tumor Hospital of Harbin Medical University,Harbin 150081,China |
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| Abstract: | Tricho-rhinophalangeal syndrome-1 gene(TRPS1),a new GATA family member,is highly prevalent in many tissues.It plays an important role in the regulation of cell proliferation and tissue development.The genetic missing of TRPS1 may lead to Tricho-rhinophalangeal syndrome.In recent years,studies have demonstrated that TRPS1 abnormal expression exists in a variety of tumors,and is associated with carcinogenesis,lymph node metastasis,pathological grading and clinical staging.Therefore,TRPS1 is considered as a potential tumor suppressor gene,its overexpression may be one of mechanisms for carcinogenesis and progression of cancer.This review focuses on the role of TRPS1 gene in carcinogenesis and progression of carcinoma,and further to provide a new biomarker for predicting cancer prognosis and therapy. |
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