| 外泌体在非小细胞肺癌中的研究进展 |
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| 引用本文： | 陈 婷,蒋晓东. 外泌体在非小细胞肺癌中的研究进展[J]. 现代肿瘤医学, 2022, 0(11): 2073-2076. DOI: 10.3969/j.issn.1672-4992.2022.11.033 |
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| 作者姓名： | 陈 婷 蒋晓东 |
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| 作者单位： | 徐州医科大学附属连云港医院放疗科，江苏 连云港 222002 |
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| 基金项目： | 江苏省研究生科研与实践创新计划（编号:SJCX19_0943） |
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| 摘 要： | 肺癌发病率和死亡率位居世界癌症前列。超过80%的肺癌为非小细胞肺癌(non-small cell lung cancer，NSCLC)，大多数患者在最初就诊时已出现局部进展或转移性疾病。外泌体是一种膜结合纳米囊泡，由活细胞释放，含有多种生物分子，如蛋白质、RNA、代谢物，甚至是药理化合物。外泌体广泛地分布于体液中，包括血浆、唾液、母乳、脑脊液等。越来越多的证据表明，外泌体在NSCLC的发生、微环境、治疗和耐药等方面发挥着重要作用。在这篇综述中，我们将对NSCLC来源的外泌体在肿瘤生长、转移、免疫应答和耐药等方面的作用进行综述。最后，我们将展望外泌体在非小细胞肺癌中的临床价值。
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| 关 键 词： | 外泌体 非小细胞肺癌 肿瘤微环境 耐药 |
Research progress of exosomes in non-small cell lung cancer |
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| CHEN Ting,JIANG Xiaodong. Research progress of exosomes in non-small cell lung cancer[J]. Journal of Modern Oncology, 2022, 0(11): 2073-2076. DOI: 10.3969/j.issn.1672-4992.2022.11.033 |
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| Authors: | CHEN Ting JIANG Xiaodong |
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| Affiliation: | Department of Radiotherapy,the Affiliated Lianyungang Hospital of Xuzhou Medical University,Jiangsu Lianyungang 222002,China. |
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| Abstract: | Lung cancer ranks first in cancer-related morbidity and death worldwide.Greater than 80% of lung cancers are attributed to non-small cell lung cancer(NSCLC),and most patients have got locally advanced or metastatic disease at the initially diagnosis.Exosomes,membrane-bound nanovesicles,are released by alive cells and contain a variety of biomolecules such as proteins,RNA,metabolites,and even pharmacological compounds.Exosomes are widely distributed in body fluids,including plasma,saliva,breast milk,and cerebrospinal fluid.Accumulating evidence suggests that exosomes play a crucial role in the development,microenvironment,anti-cancer drug resistance and therapy of NSCLC.In this review,we will summarize the effects of NSCLC-derived exosomes in tumor growth,metastasis,immune response and drug resistance.Finally,we will prospect the clinical value of exosomes in NSCLC. |
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| Keywords: | exosomes non-small cell lung cancer tumor microenvironment drug resistance |
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