| 重复经颅磁刺激联合舍曲林对首发青少年抑郁早期疗效及冷执行功能的影响 |
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| 引用本文： | 陈海思,高静芳,王晓乐,胡希文. 重复经颅磁刺激联合舍曲林对首发青少年抑郁早期疗效及冷执行功能的影响[J]. 中华全科医学, 2022, 20(9): 1491-1494. DOI: 10.16766/j.cnki.issn.1674-4152.002631 |
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| 作者姓名： | 陈海思 高静芳 王晓乐 胡希文 |
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| 作者单位： | 1.浙江大学医学院附属精神卫生中心，杭州市第七人民医院，浙江 杭州 310013 |
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| 基金项目： | 浙江省医药卫生科技计划项目2020KY747 |
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| 摘 要： | 目的 探讨重复经颅磁刺激联合舍曲林对首发青少年抑郁症早期抗抑郁作用及冷执行功能的影响。方法 选取2021年3—6月杭州市第七人民医院收治的首发青少年抑郁症患者77例，按随机数字法分为研究组(38例)和对照组(39例)。2组均予舍曲林(第1周25 mg/d, 2周内增至100 mg/d),研究组加用2周重复经颅磁刺激治疗(1次/d, 5次/周)。治疗前后采用汉密尔顿抑郁量表(HAMD-17)、儿童抑郁评定量表(CDRS-R)、视听整合持续操作测验(IVA-CPT)及THINC-it评估抑郁症状及冷执行功能。结果 研究组早期改善率为92.11%(35/38),高于对照组的71.79%(28/39,P<0.05);治疗第2、4周后，2组HAMD-17及CDRS-R评分较治疗前下降，治疗后研究组评分低于对照组(均P<0.05);治疗4周后，研究组注意力商数[听、视、综合分别为(98.24±20.72)分、(90.00±21.97)分、(94.24±21.43)分]高于对照组[(82.62±27.71)分、(78.10±27.85)分、(80.21±24.47)分],差异有统计学意义...
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| 关 键 词： | 青少年 抑郁症 重复经颅磁刺激 冷执行功能 |
| 收稿时间： | 2021-07-07 |
Early effects and impacts on cold executive function of repetitive transcranial magnetic stimulation combined with sertraline in first-episode adolescent depression |
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| Affiliation: | Psychosomatic Department, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310013, China |
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| Abstract: | Objective To explore the early effects and impacts on cold executive function of repetitive transcranial magnetic stimulation (rTMS) combined with sertraline in adolescents with first-episode major depressive disorder. Methods A total of 77 adolescent patients with first-episode depression from Hangzhou 7th Hospital were divided into study group (38 cases) and control group (39 cases) by random number method. The control group was treated with sertraline (25 mg/d in first week, up to 100 mg/ d in 2 weeks). The study group was given sertraline combined with rTMS (1 time/d, 5 times/ week). Depressive symptoms and cold executive function before and after treatment were evaluated using Hamilton Depression Scale (HAMD-17), children's Depression Rating Scale (CDRS-R), audiovisual integration continuous operation test (IVA-CPT) and THINC-it. Results The early improvement rate in the study group was 92.11% (35/38), higher than 71.79% (28/39) in the control group (P < 0.05). After 2 and 4 weeks of treatment, the HAMD-17 and CDRs-R scores of the two groups decreased compared with those before treatment, and the scores of the study group were lower than those of the control group after treatment (all P < 0.05). After 4 weeks of treatment, the attention quotient (listening, visual and full-scale) in the study group [(98.24±20.72) points, (90.00±21.97) points, (94.24±21.43) points] was higher than that in the control group [(82.62±27.71) points, (78.10±27.85) points, (80.21±24.47) points], and the difference was statistically significant (all P < 0.05). Both two groups improved statistically significant in Spotter, Symbol Check, Codebreake, and Trails (all P < 0.05). The study group showed significantly higher score in PDQ5 in THINC-it after treatment (P < 0.05). Conclusion Sertraline combined with rTMS can early improve the clinical symptoms and cold executive function of first-episode adolescent depression patients. |
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