| 肾素-血管紧张素系统与肿瘤关系的研究进展 |
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| 引用本文： | 刘方芳1,' target='_blank'>2,龚祖康3,梁海雷1,' target='_blank'>2,武文奕1,' target='_blank'>2,张祖霖1,' target='_blank'>2,贺菽嘉1,' target='_blank'>2,赵瑞强1,' target='_blank'>2,周青鸟1,' target='_blank'>2,林文珍1,' target='_blank'>2. 肾素-血管紧张素系统与肿瘤关系的研究进展[J]. 现代肿瘤医学, 2022, 0(8): 1495-1499. DOI: 10.3969/j.issn.1672-4992.2022.08.032 |
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| 作者姓名： | 刘方芳1 ' target='_blank'>2 龚祖康3 梁海雷1 ' target='_blank'>2 武文奕1 ' target='_blank'>2 张祖霖1 ' target='_blank'>2 贺菽嘉1 ' target='_blank'>2 赵瑞强1 ' target='_blank'>2 周青鸟1 ' target='_blank'>2 林文珍1 ' target='_blank'>2 |
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| 作者单位： | 1.广西医科大学生物化学与分子生物学教研室,广西 南宁 530021;2.广西高校生物分子医学重点实验室,广西 南宁 530021;3.南宁市疾病预防控制中心,广西 南宁 530021 |
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| 基金项目： | National Natural Science Foundation of China(No.81660464,81160263）;国家自然科学基金项目（编号:81660464,81160263）;广西自然科学基金（编号:2016GXNSFAA380275） |
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| 摘 要： | 肾素-血管紧张素系统（renin-angiotensin system,RAS）是人类重要的体液调节系统,对维持心血管内稳态和水电解质平衡至关重要,近年来的研究显示RAS与肿瘤发生发展、血管的形成和转移密切相关。RAS主要通过经典的ACE-AngⅡ-AT1轴以及ACE2-Ang(1-7)-Mas替代轴发挥作用,ACE-AngⅡ-AT1轴与导致肿瘤的生物学过程相关,ACE2-Ang(1-7)-Mas轴是ACE-AngⅡ-AT1轴的反向调节轴,ACE2-Ang(1-7)-Mas轴的激活对大多数肿瘤增殖和转移起抑制作用,本文现就这两条轴与肿瘤的关系进行阐述。
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| 关 键 词： | 肿瘤 肾素-血管紧张素系统 血管紧张素Ⅱ 血管紧张素Ⅱ1型受体 血管紧张素（1-7） 血管紧张素转化酶2 |
Progress of the relationship between renin-angiotensin system and tumor |
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| LIU Fangfang,' target='_blank'>,GONG Zukang,LIANG Hailei,' target='_blank'>,WU Wenyi,' target='_blank'>,ZHANG Zulin,' target='_blank'>,HE Shujia,' target='_blank'>,ZHAO Ruiqiang,' target='_blank'>,ZHOU Qingniao,' target='_blank'>,LIN Wenzhen,' target='_blank'>. Progress of the relationship between renin-angiotensin system and tumor[J]. Journal of Modern Oncology, 2022, 0(8): 1495-1499. DOI: 10.3969/j.issn.1672-4992.2022.08.032 |
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| Authors: | LIU Fangfang ' target='_blank'> GONG Zukang LIANG Hailei ' target='_blank'> WU Wenyi ' target='_blank'> ZHANG Zulin ' target='_blank'> HE Shujia ' target='_blank'> ZHAO Ruiqiang ' target='_blank'> ZHOU Qingniao ' target='_blank'> LIN Wenzhen ' target='_blank'> |
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| Affiliation: | 1.Department of Biochemistry and Molecular Biology,Guangxi Medical University,Guangxi Nanning 530021,China;2.Key Laboratory of Biomolecular Medicine,Guangxi University,Guangxi Nanning 530021,China;3.Nanning Center for Disease Control and Prevention,Guangxi Nanning 530021,China. |
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| Abstract: | The renin-angiotensin system (RAS) is an important humoral regulatory system in human and essential for maintaining cardiovascular homeostasis and water-electrolyte balance.Recent studies have shown that RAS is closely related to tumor development,vascular formation and metastasis.RAS mainly acts through the classical ACE-AngⅡ-AT1 axis and the ACE2-Ang(1-7)-Mas alternative axis.The ACE-AngⅡ-AT1 axis is associated with the biological processes leading to tumors,while the ACE2-Ang(1-7)-Mas axis is the counter-regulatory axis of the ACE-AngⅡ-AT1 axis.The activation of the ACE2-Ang(1-7)-Mas axis plays an inhibitory role in the proliferation and metastasis of most tumors.In this paper,the relationship between these two axes and tumors was described. |
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| Keywords: | tumor renin-angiotensin system angiotensin Ⅱ angiotensin Ⅱ type 1 receptor angiotensin(1-7) angiotensin-converting enzyme 2 |
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