| 神经周围浸润与早期舌鳞状细胞癌患者临床病理特征的相关性及对预后的影响 |
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| 引用本文： | 闫广鹏,刘 坤,唐志岩,陈 炼,李 军. 神经周围浸润与早期舌鳞状细胞癌患者临床病理特征的相关性及对预后的影响[J]. 现代肿瘤医学, 2022, 0(7): 1206-1209. DOI: 10.3969/j.issn.1672-4992.2022.07.012 |
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| 作者姓名： | 闫广鹏 刘 坤 唐志岩 陈 炼 李 军 |
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| 作者单位： | 新疆维吾尔自治区人民医院口腔颌面外科，新疆 乌鲁木齐 830000 |
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| 基金项目： | 新疆维吾尔自治区自然科学基金（编号:2019D01C096） |
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| 摘 要： | 目的:探讨神经周围浸润（perineural invasion,PNI）与早期舌鳞状细胞癌（tongue squamous cell carcinoma，TSCC）患者临床病理特征的相关性及对预后的影响。方法:收集75例早期TSCC患者的完整病例资料，观察PNI情况并分析其与TSCC临床病理特征的关系及对患者5年生存率和生存期的影响。结果:PNI阳性与性别、年龄、临床分期差异均无统计学意义（P＞0.05）；PNI阳性与分化程度、淋巴结转移、浸润深度、淋巴脉管浸润、手术切缘阳性差异均有统计学意义（P＜0.05）。PNI阳性患者5年生存率及生存期均明显低于PNI阴性者（P＜0.05）。COX多因素回归分析表明PNI阳性是早期TSCC患者术后预后的独立危险因素（P＜0.05）。结论:PNI阳性对早期TSCC患者的预后有影响，对早期TSCC患者预后辅助治疗的方案设计具有一定的参考价值，并且可以作为早期TSCC患者预后判断的独立危险因素。
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| 关 键 词： | 神经周围浸润 舌鳞状细胞癌 临床病理特征 预后 危险因素 辅助治疗 |
Correlation between perineural infiltration and clinicopathological features in patients with early tongue squamous cell carcinoma and its influence on prognosis |
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| YAN Guangpeng,LIU Kun,TANG Zhiyan,CHEN Lian,LI Jun. Correlation between perineural infiltration and clinicopathological features in patients with early tongue squamous cell carcinoma and its influence on prognosis[J]. Journal of Modern Oncology, 2022, 0(7): 1206-1209. DOI: 10.3969/j.issn.1672-4992.2022.07.012 |
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| Authors: | YAN Guangpeng LIU Kun TANG Zhiyan CHEN Lian LI Jun |
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| Affiliation: | Department of Maxillofacial Surgery,People's Hospital of Xinjiang Uygur Autonomous Region,Xinjiang Urumqi 830000,China. |
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| Abstract: | Objective:To investigate the correlation between perineural infiltration(PNI) and clinicopathological features in patients with early tongue squamous cell carcinoma(TSCC) and its influence on prognosis.Methods:Data of 75 patients with early TSCC were collected to observe the relationship between PNI and the clinicopathological characteristics of TSCC and analysis the effect on 5-year survival and survival of patients.Results:There were no significant difference between PNI positivity and gender，age and clinical stage（P>0.05).There were significant difference between PNI positivity and differentiation degree，lymph node metastasis，depth of invasion，lymphatic vascular invasion and surgical margin（P<0.05).The 5-year survival rate and survival time of PNI-positive patients were significantly lower than those of PNI-negative patients.COX multivariate regression analysis showed that PNI positivity was an independent risk factor for postoperative prognosis of early TSCC patients（P＜0.05）.Conclusion:PNI positivity has an impact on the prognosis of early TSCC patients，and has a certain reference value for the design of adjuvant therapy for early TSCC patients，and can be used as an independent risk factor for the prognosis judgment of early TSCC patients. |
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| Keywords: | perineural invasion(PNI) tongue squamous cell cancer clinicopathological prognosis risk factor adjuvant therapy |
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