胃癌患者术前天冬氨酸转氨酶和丙氨酸转氨酶比值与临床病理特征的关系及其预后价值
《现代肿瘤医学》[ISSN:1672-4992/CN:61-1415/R]
- 期数:
- 2022年19期
- 页码:
- 3528-3533
- 栏目:
- 论著（消化肿瘤）
- 出版日期:
- 2022-08-30
文章信息/Info
- Title:
- Relationship between preoperative aspartate aminotransferase to alanine aminotransferase ratio and clinicopathological features and its prognostic value in patients with gastric cancer
- Author(s):
- SHI Litong; WANG Wenjia; QIN Yanru
- Department of Oncology,First Affiliated Hospital of Zhengzhou University,Henan Zhengzhou 450052,China.
- 分类号:
- R735.2
- DOI:
- 10.3969/j.issn.1672-4992.2022.19.016
- 文献标识码:
- A
- 摘要:
- 目的：探讨胃癌患者术前天冬氨酸转氨酶（aspartate aminotransferase,AST）和丙氨酸转氨酶（alanine aminotransferase,ALT）比值（SLR）与临床病理特征的关系及其预后价值。方法：回顾性分析2011年05月至2018年12月我院收治的667例行胃癌根治术患者的临床资料并随访，根据术前SLR水平最佳截点进行分组。采用Kaplan-Meier法和Cox模型分析确定胃癌患者独立危险因素，最终构建列线图预后模型。结果：术前SLR水平最佳截点为1.28，SLR<1.28组331例，SLR≥1.28组336例。SLR<1.28组胃癌患者的1、3、5年生存率分别为94.6%、71.8% 和 50.2%，而 SLR≥1.28组分别为86.5%、55.9%和39.8%，差异具有统计学意义（χ2=15.817，P＜0.000 1）。患者总生存期（overall survival，OS）与年龄、肿瘤直径、肿瘤分化程度、TNM分期、CA199水平和SLR水平相关（P＜0.05）。应用上述风险因素构建列线图预后模型，C指数为0.681。结论：SLR水平是胃癌患者预后的独立危险因素，其简便易测、价格低廉，可以有效评估胃癌患者的预后，对个体化治疗策略的选择具有重要意义。
- Abstract:
- Objective：To investigate the relationship between the ratio of aspartate aminotransferase（AST) and alanine aminotransferase（ALT) to clinical pathological characteristics and its prognostic value in patients with gastric cancer.Methods:Retrospectively analysis of clinical data and follow-up of 667 patients diagnosed with GC in our hospital from May 2011 to December 2018.Group according to the cut-off value of the preoperative SLR level.The Kaplan-Meier method and Cox model were used to analyze and determine independent risk factors for gastric cancer patients,which were used to build nomogram.Results:The cut-off value of SLR level was 1.28,331 cases in SLR<1.28 group and 336 cases in SLR≥1.28 group.The survival rates of 1,3 and 5 years were 94.6%,71.8% and 50.2% respectively in SLR<1.28 group of gastric cancer patients,while the survival rates of SLR≥1.28 were 86.5%,55.9% and 39.8%,respectively.The difference was statistically significant（χ2=15.817,P＜0.000 1).The overall survival(OS) of patients was related to age,tumor diameter,tumor differentiation,TNM staging,CA199 level and SLR level（P＜0.05).The above risk factors were used to construct a nomogram with a C index of 0.681.Conclusion:SLR level is an independent risk factor for the prognosis of gastric cancer patients,which is simple to measure and low in price,and can effectively evaluate the prognosis of gastric cancer patients.It is of great significance to the choice of individualized treatment strategy.
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备注/Memo
- 备注/Memo:
- National Natural Science Foundation of China（No.81872264）;国家自然科学基金资助项目(编号：81872264)
