| miR-1301-3p与甲状腺乳头状癌中央区淋巴结转移的相关性探讨 |
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| 引用本文： | 乔德辉1,杨 辉1,周 阳1,邓 显1,何雪梅2,周翔宇1. miR-1301-3p与甲状腺乳头状癌中央区淋巴结转移的相关性探讨[J]. 现代肿瘤医学, 2022, 0(17): 3106-3110. DOI: 10.3969/j.issn.1672-4992.2022.17.008 |
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| 作者姓名： | 乔德辉1 杨 辉1 周 阳1 邓 显1 何雪梅2 周翔宇1 |
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| 作者单位： | 1.西南医科大学附属医院甲状腺外科;2.中心实验室，四川 泸州 646000 |
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| 基金项目： | 中国宋庆龄基金会呼吸疾病临床研究公益基金（编号:2018MZFT-176） |
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| 摘 要： | 目的:研究miR-1301-3p在甲状腺乳头状癌（papillary thyroid carcinoma,PTC）中表达的变化，分析miR-1301-3p与PTC中央区淋巴结转移的关系。方法:选取2018年08月至2019年08月在我院诊断为“甲状腺肿瘤”的患者60例，其中PTC 30例。qRT-PCR检测miR-1301-3p在良、恶性肿瘤组织，及PTC术前、术后血清中的表达。分析miR-1301-3p与中央区淋巴结转移的关系。ROC曲线分析miR-1301-3p对甲状腺肿瘤、中央区淋巴结是否转移的诊断价值。结果:miR-1301-3p在PTC组织中表达降低（P＜0.000 1），在PTC患者术后血清中表达上升(P=0.045 5)。超声对甲状腺肿瘤的诊断效能为0.726（CI:0.627~0.810，P＜0.001）；miR-1301-3p对甲状腺肿瘤的诊断效能为0.788（CI:0.695~0.864，P＜0.001）；miR-1301-3p联合超声对甲状腺肿瘤的诊断效能为0.827（CI:0.738~0.895，P＜0.001）。miR-1301-3p在有中央区淋巴结转移的PTC中表达降低。超声对中央区淋巴结是否转移的诊断效能为0.571（CI:0.410~0.723，P=0.033 9）；miR-1301-3p对中央区淋巴结是否转移的诊断效能为0.813（CI:0.662~0.916，P＜0.001）；miR-1301-3p联合超声对中央区淋巴结是否转移的诊断效能为0.872（CI:0.733~0.955），P＜0.001）。结论:miR-1301-3p在PTC组织中表达降低，与中央区淋巴结转移相关；miR-1301-3p可提高超声对甲状腺肿瘤、中央区淋巴结是否转移的诊断效能，可能为PTC潜在的肿瘤标志物。
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| 关 键 词： | 甲状腺乳头状癌 miR-1301-3p 中央区淋巴结转移 肿瘤标志物 |
The correlation between miR-1301-3p and central lymph node metastasis in papillary thyroid carcinoma |
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| QIAO Dehui1,YANG Hui1,ZHOU Yang1,DENG Xian1,HE Xuemei2,ZHOU Xiangyu1. The correlation between miR-1301-3p and central lymph node metastasis in papillary thyroid carcinoma[J]. Journal of Modern Oncology, 2022, 0(17): 3106-3110. DOI: 10.3969/j.issn.1672-4992.2022.17.008 |
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| Authors: | QIAO Dehui1 YANG Hui1 ZHOU Yang1 DENG Xian1 HE Xuemei2 ZHOU Xiangyu1 |
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| Affiliation: | 1.Department of Thyroid Surgery;2.Central Laboratory,Affiliated Hospital of Southwest Medical University,Sichuan Luzhou 646000,China. |
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| Abstract: | Objective:To determine the expression profile of miR-1301-3p in PTC and analyze the relationship between miR-1301-3p expression and central lymph node metastasis of PTC.Methods:60 patients diagnosed as "thyroid tumor" in our hospital from August 2018 to August 2019 were selected,including 30 cases of PTC.qRT-PCR was used to detect the expression of miR-1301-3p in benign,malignant tumor tissues,and preoperative,postoperative serum.The relationship between miR-1301-3p and central lymph node metastasis was analyzed.ROC curve was used to analyze the diagnostic value of miR-1301-3p in thyroid tumor and central lymph node.Results:The expression of miR-1301-3p decreased in PTC（P<0.000 1),and increased in the serum of postoperative（P=0.045 5).The diagnostic efficiency of ultrasound for thyroid tumor was 0.726（CI:0.627~0.810,P<0.001) and miR-1301-3p was 0.788（CI:0.695~0.864,P<0.001).miR-1301-3p combined with ultrasound was 0.827（CI:0.738~0.895,P<0.001).qRT-PCR and TCGA data analysis showed that miR-1301-3p decreased in PTC with central lymph node metastasis.The diagnostic efficiency of ultrasound for central lymph nodes was 0.571（CI:0.410~0.723,P=0.033 9) and miR-1301-3p for central lymph nodes was 0.813（CI:0.662~0.916,P＜0.001).miR-1301-3p combined with ultrasound for central lymph nodes was 0.872（CI:0.733~0.955,P<0.001).Conclusion:miR-1301-3p expression is decreased in PTC,and it is associated with central lymph node metastasis,miR-1301-3p can be used as a tumor marker for PTC diagnosis and preoperative management. |
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| Keywords: | papillary thyroid carcinoma miR-1301-3p central lymph node metastasis tumor marker |
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