| 整合素RGD受体显像临床应用专家共识(2022版) |
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| 引用本文： | 中华医学会核医学分会,中国生物物理学会分子影像学分会. 整合素RGD受体显像临床应用专家共识(2022版)[J]. 协和医学杂志, 2022, 13(2): 227-234. DOI: 10.12290/xhyxzz.2022-0089 |
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| 作者姓名： | 中华医学会核医学分会 中国生物物理学会分子影像学分会 |
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| 基金项目： | 国家自然科学基金81871392中国医学科学院医学与健康科技创新工程2021-I2M-1-016首都卫生发展科研专项2018-1-4011广州实验室应急攻关项目EKPG21-16中国医学科学院临床转化基金2019XK320032 |
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| 摘 要： | 整合素是一类跨膜糖蛋白,介导细胞与细胞、细胞与细胞外间质之间的黏附及信号传导,调节细胞的黏附、迁移、增殖和凋亡等功能,在新生血管内皮细胞及多种恶性肿瘤细胞表面高表达.基于精氨酸-甘氨酸-天冬氨酸(arginine-glycine-aspartate,RGD)结构的多肽能够与整合素αVβ3等亚型特异结合,通过单光子发射计...
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| 关 键 词： | 整合素 受体显像 精氨酸-甘氨酸-天冬氨酸多肽 临床应用专家共识 |
| 收稿时间： | 2022-02-27 |
Expert Consensus on Clinical Application of Integrin RGD Receptor Imaging (2022) |
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| Abstract: | Integrin is a group of transmembrane glycoprotein that mediates cell-cell adhesion and signal transduction. It regulates cell adhesion, migration, proliferation, apoptosis and other functions. It is highly expressed on the surface of neovascular endothelial cells and a variety of malignant tumor cells. The peptides witharginine-glycine-aspartate (RGD) motif can specifically bind to multiplesubtypes of integrin including αVβ3. When labeled with radionuclides for single photon emission tomography (SPECT) or positron emission tomography (PET), the RGD-based peptides can non-invasively reveal the tumor characteristics, including invasion and metastasis, as well as evaluate angiogenesis in vivo. These methods have shown strong value in clinical application. Based on the home-and-abroad progress in relevant clinical research, this expert consensus aims to establish principles for clinical application of RGD-based peptides to integrin imaging. |
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