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| 2型糖尿病与非糖尿病患者腰椎骨髓脂肪分数值定量比较 | |
| 引用本文： | 崔凤珍,王世雷,赵月芹,张哲,曹江欣. 2型糖尿病与非糖尿病患者腰椎骨髓脂肪分数值定量比较[J]. 河北医科大学学报, 2022, 43(11): 1311-1317. DOI: 10.3969/j.issn.1007-3205.2022.11.015 |
| 作者姓名： | 崔凤珍 王世雷 赵月芹 张哲 曹江欣 |
| 作者单位： | 1.河北省石家庄市第二医院医学影像科，河北 石家庄 050051；2.河北省石家庄市第三医院导管室，河北 石家庄 050051 |
| 基金项目： | 石家庄市科学技术研究与发展计划项目(211460463) |
| 摘 要： | 目的 比较2型糖尿病(type 2 diabetes mellitus, T2DM)与非糖尿病患者腰椎骨髓脂肪含量。方法 前瞻性选择行腰椎MRI检查的患者100例，均采用磁共振非对称回波最小二乘估算法迭代水脂分离(water and fat with Echo Asymmetry and Least squares estimation, IDEAL)序列扫描。测量腰椎骨髓IDEAL-fat、IDEAL-water信号值，计算腰椎骨髓脂肪分数值(bone marrow fat fraction, BMFFIDEAL)。比较T2DM组和非糖尿病组腰椎骨髓IDEAL-fat、IDEAL-water平均信号值、BMFFIDEAL值，并分析与性别、年龄、体重指数(body mass index, BMI)及糖化血红蛋值的关系。结果 T2DM组、非糖尿病组腰椎骨髓IDEAL-fat和IDEAL-water平均信号值差异无统计学意义(P>0.05),T2DM组腰椎骨髓BMFFIDEAL值高于非糖尿病组(P<0.05)。T... |
| 关 键 词： | 糖尿病,2型 腰椎 骨髓 磁共振成像 |
Quantitative analysis of lumbar bone marrow fat content in patients with type 2 diabetes mellitus and non-diabetic patients |
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| CUI Feng-zhen,WANG Shi-lei,ZHAO Yue-qin,ZHANG Zhe,CAO Jiang-xin. Quantitative analysis of lumbar bone marrow fat content in patients with type 2 diabetes mellitus and non-diabetic patients[J]. Journal of Hebei Medical University, 2022, 43(11): 1311-1317. DOI: 10.3969/j.issn.1007-3205.2022.11.015 | |
| Authors: | CUI Feng-zhen WANG Shi-lei ZHAO Yue-qin ZHANG Zhe CAO Jiang-xin |
| Affiliation: | 1.Department of Radiology, the Second Hospital of Shijiazhuang City, Hebei Province, Shijiazhuang 050051， China； 2.Department of Catheter Lab, the Third Hospital of Shijiazhuang City, Hebei Province, Shijiazhuang 050051， China |
| Abstract: | Objective To compare the bone marrow fat(BMF) content of lumbar spine between type 2 diabetes mellitus(T2DM) patients and non-diabetic patients.Methods We conducted a prospective analysis of 100 patients who underwent lumbar MRI iterative decomposition of water and fat with echo asymmetry and least-squares estimation(IDEAL) sequence. The IDEAL-fat and IDEAL-water signal values of lumbar bone marrow were measured. The BMF fraction(BMFFIDEAL) was calculated. The difference of mean IDEAL-fat signal value, mean IDEAL-water signal value and the BMFFIDEAL value of lumbar bone marrow between T2DM group and non-diabetic group were compared, and their correlation with age, gender, body mass index(BMI) and glycated hemoglobin A 1c(HbAlc) were analyzed.Results There was no significant difference in the mean IDEAL-fat signal value and mean IDEAL-water signal value of lumbar bone marrow between T2DM group and non-diabetic group(P＞0.05). The BMFFIDEAL value of lumbar bone marrow in T2DM group was higher than that in non-diabetic group(P＜0.05). There was no significant difference in the BMFFIDEAL value of lumbar bone marrow between male and female group, and between normal group and overweight group in T2DM group(P＞0.05), as well as in non-diabetic group(P＞0.05). There was no significant difference in the IDEAL-fat value among L1-L5 in both T2DM group and non-diabetic group(P＞0.05). There was significant difference in the IDEAL-water value and BMFFIDEAL value among L1-L5 in both T2DM group and non-diabetic group(P＜0.05). The BMFFIDEAL value of L1 of bone marrow was lower than that of L3 in T2DM group. The IDEAL-water value of L1 was higher than that of L3， and BMFFIDEAL value of L1 was lower than that of L3and L4 in non-diabetic group(P＜0.05). The BMFFIDEAL value of lumbar bone marrow was positively correlated with age in T2DM group and non-diabetic group. The BMFFIDEAL value of lumbar bone marrow was positively correlated with HbAlc value in T2DM group(P＜0.05).Conclusion The BMF content of lumbar spine in T2DM patients was higher than that in non-diabetic patients, which is associated with age and HbAlc, but not related to gender and BMI. |
| Keywords: | diabetes mellitus type 2 lumbar vertebrae bone marrow magnetic resonance imaging |
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