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| 宫颈癌组织中HPV16E6、E7蛋白水平与患者临床病理特征及预后的关系 | |
| 引用本文： | 路玲,张媛媛,徐瑶,吴宝华,徐蕾,吴海燕. 宫颈癌组织中HPV16E6、E7蛋白水平与患者临床病理特征及预后的关系[J]. 河北医科大学学报, 2022, 43(8): 931-934+955. DOI: 10.3969/j.issn.1007-3205.2022.08.013 |
| 作者姓名： | 路玲 张媛媛 徐瑶 吴宝华 徐蕾 吴海燕 |
| 作者单位： | 1.成都医学院第一附属医院妇科，四川 成都 610500；2.新疆医科大学附属肿瘤医院妇科，新疆 乌鲁木齐 830054 |
| 基金项目： | 高层次人才科研启动基金项目（CYFY-GQ33） |
| 摘 要： | 目的 探究宫颈癌组织中16型人乳头瘤病毒E6蛋白(human papilloma virus type 16 E6 protein, HPV16 E6)、16型人乳头瘤病毒E7蛋白(human papilloma virus type 16 E6 protein, HPV16 E7)水平与患者临床病理特征及预后的关系。方法 选取行宫颈癌根治术87例患者的肿瘤组织、癌旁组织、正常宫颈组织标本进行研究，采用免疫组织化学法检测组织中HPV16 E6、HPV16 E7蛋白表达情况，并结合患者临床病理特征进行分析，采用Kaplan-Meier生存曲线比较患者3年生存情况，采用COX回归分析各项因素对患者预后的影响。结果 免疫组化结果显示肿瘤组织中HPV16 E6、HPV16 E7阳性率高于癌旁组织和正常组织(P<0.05); HPV16 E6及HPV16 E7蛋白阳性表达患者3年生存率低于阴性表达患者(P<0.05);多因素分析显示HPV16 E6、HPV16 E7阳性是宫颈癌患者预后不良的独立危险因素(P<0.05)。结论 HPV16 E6、HPV16 E7蛋白在宫颈癌组织中... |
| 关 键 词： | 宫颈肿瘤 16型人乳头瘤病毒E6蛋白 16型人乳头瘤病毒E7蛋白 |
The relationship of HPV16 E6, E7 protein levels in cervical cancer tissues with clinical characteristics and prognosis |
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| LU Ling,ZHANG Yuan-yuan,XU Yao,WU Bao-hua,XU Lei,WU Hai-yan. The relationship of HPV16 E6, E7 protein levels in cervical cancer tissues with clinical characteristics and prognosis[J]. Journal of Hebei Medical University, 2022, 43(8): 931-934+955. DOI: 10.3969/j.issn.1007-3205.2022.08.013 | |
| Authors: | LU Ling ZHANG Yuan-yuan XU Yao WU Bao-hua XU Lei WU Hai-yan |
| Affiliation: | 1.Department of Gynecology, the First Affiliated Hospital of Chengdu Medical College, Sichuan Province, Chengdu 610500, China; 2.Department of Gynecology,the Affiliated Cancer Hospital of Xinjiang Medical University, Xinjiang Province, Urumqi 830054, China |
| Abstract: | Objective To explore the relationship of the levels of human papilloma virus E6 protein(HPV16 E6) and human papilloma virus E7 protein(HPV16 E7) in cervical cancer tissues with the clinical characteristics and prognosis of patients.Methods The tumor tissue, adjacent tissue, and normal cervical tissue specimens of 87 patients undergoing radical cervical cancer surgery were selected for research. Immunohistochemistry was used to detect the expression of HPV16 E6 and HPV16 E7 proteins in the tissues for analysis by combining the clinicopathological characteristics of the patients. Kaplan-Meier survival curve was used to compare the 3-year survival of the patients, and the COX regression analysis was used to analyze the effect of various factors on the prognosis of the patients.Results Immunohistochemical results showed that the positive rates of HPV16 E6 and HPV16 E7 in tumor tissues were higher than those in adjacent tissues and normal tissues(P＜0.05), and the 3-year survival rate of patients with positive expression of HPV16 E6 and HPV16 E7 protein was lower than that of patients with negative expression(P＜0.05). Multivariate analysis showed that HPV16 E6 and HPV16 E7 were independent risk factors for poor prognosis in patients with cervical cancer(P＜0.05).Conclusion HPV16 E6 and HPV16 E7 proteins are positively expressed in cervical cancer tissues, which are related to the clinicopathological characteristics and prognosis of patients, and may play a role as new targets for the treatment of cervical cancer. |
| Keywords: | uterine cervical neoplasms human papilloma virus type 16 E6 protein human papilloma virus type 16 E7 protein |
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