Nevirapine plasma exposure affects both durability of viral suppression and selection of nevirapine primary resistance mutations in a clinical setting |
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| Authors: | González de Requena D Bonora S Garazzino S Sciandra M D'Avolio A Raiteri R Marrone R Boffito M De Rosa F G Sinicco A Di Perri G |
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| Affiliation: | Department of Infectious Diseases, University of Turin, Italy. |
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| Abstract: | The relationship between nevirapine plasma concentrations and the durability of both viral suppression (VS) and selection of nevirapine primary resistance mutations (PRMs) was evaluated. A nevirapine trough concentration (Ctrough) of >4,300 ng/ml was found to predict longer VS. Patients with nevirapine Ctrough s ranging from 3,100 to 4,300 ng/ml had higher probabilities of developing PRMs than those with nevirapine Ctrough s below and above this concentration interval. |
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