| 妊娠期高血压病患者血清细胞粘附分子-1 和白细胞介素-6 的变化 |
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| 引用本文： | 申霞. 妊娠期高血压病患者血清细胞粘附分子-1 和白细胞介素-6 的变化[J]. 新乡医学院学报, 2006, 23(5): 522-524 |
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| 作者姓名： | 申霞 |
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| 作者单位： | (河南中医学院第一附属医院妇产科,河南 郑州 450000) |
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| 摘 要： | 目的探讨血清细胞粘附分子-1(VCAM-1)、白细胞介-素6(IL-6)在妊娠期高血压疾病发病中的作用。方法采用ELISA法分别测定24例妊娠期高血压患者、28例重度子前期患者2、8例轻度子前期患者及30例正常妊娠妇女血清中VCAM-1、IL-6。结果观察组患者血清中VCAM-1和IL-6水平显著高于对照组(P<0.01)。重度子痫前期组血清中VCAM-1和IL-6的表达显著高于妊娠高血压组(P<0.05);轻度子痫前期组血清中VCAM-1和IL-6的表达显著高于对照组(P<0.05)。各组患者血清中VCAM-1的表达与IL-6呈正相关(r=0.653,P<0.05)。结论VCAM-1和IL-6在妊娠期高血压疾病的发生、发展中起重要作用。
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| 关 键 词： | 细胞粘附分子21 白细胞介素-6 妊娠期高血压疾病 |
| 文章编号： | 1004-7239（2006）05-0522-03 |
| 收稿时间： | 2006-06-10 |
| 修稿时间： | 2006-06-10 |
Detection of serum interleukin-6 and cell adhesion molecule-1 in patients with hypertensive disease of pregnancy |
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| SHEN Xia. Detection of serum interleukin-6 and cell adhesion molecule-1 in patients with hypertensive disease of pregnancy[J]. Journal of Xinxiang Medical College, 2006, 23(5): 522-524 |
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| Authors: | SHEN Xia |
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| Affiliation: | Department of Obstetrics and Gynecology, the First Affiliated Hospital of Henna College of TCM, Henan Zhengzhou 450008 |
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| Abstract: | Objective To study the role of serum cell adhesion molecule-1(VCAM-1),interleukin-6(IL-6) in pathogenesis of patients with hypertensive disease of pregnancy.Methods Serum IL-6 and VCAM-1 levels were measured by using ELISA in 28 severe preeclampsia patients,28 mild preeclampsia patients,and 30 normal pregnant women.Results The levels of serum VCAM-1 and IL-6 in observation group were significant higher than those of control group(P<0.01).The levels of VCAM-1 and IL-6 in group of severe pre-eclampsia were significantly higher than those in the group of normal pregnants(P<0.05).The levels of VCAM-1 and IL-6 in group of mild preeclampsia were higer than those in the group of control group.The levels of serum VCAM-1 was positive correlation to the level of serum IL-6 in patients of different groups.Conclusion The VCAM-1 and IL-6 play important roles in the pathogenesis and development of hypertensive disease of pregnancy. |
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| Keywords: | vascular cell adhesion molecule-1 interleukin-6 hypertensive disease of pregnancy |
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